Abstract

The purpose of this project is the analysis of the effects of neonatal oxytocin (OT) manipulations on subsequent sexual and social behaviors in prairie voles. This project will focus on female socio-sexual behavior and an index of responsivity to estrogen in female rats and voles that have been exposed to neonatal OT manipulations. In addition, the effects of OT on these behaviors will be studied in adulthood as a function of neonatal manipulations of OT. Other behavioral endpoints included exploratory behavior will be used in conjunction with these studies.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Program Projects (P01)
Project #
3P01HD038490-03S1
Application #
6594445
Study Section
Special Emphasis Panel (ZHD1)
Project Start
2002-06-01
Project End
2003-02-28
Budget Start
Budget End
Support Year
3
Fiscal Year
2002
Total Cost
$129,677
Indirect Cost

  Institution

Name
University of Maryland College Park
Department
Type
DUNS #
City
College Park
State
MD
Country
United States
Zip Code
20742

  Publications

Kenkel, William M; Carter, C Sue (2016) Voluntary exercise facilitates pair-bonding in male prairie voles. Behav Brain Res 296:326-330
Kenkel, William M; Yee, Jason R; Porges, Stephen W et al. (2015) Cardioacceleration in alloparents in response to stimuli from prairie vole pups: the significance of thermoregulation. Behav Brain Res 286:71-9
Kenkel, William M; Suboc, Gessa; Carter, C Sue (2014) Autonomic, behavioral and neuroendocrine correlates of paternal behavior in male prairie voles. Physiol Behav 128:252-9
Kenkel, William M; Paredes, Jamespaul; Lewis, Gregory F et al. (2013) Autonomic substrates of the response to pups in male prairie voles. PLoS One 8:e69965
Pournajafi-Nazarloo, Hossein; Partoo, Leila; Yee, Jason et al. (2011) Effects of social isolation on mRNA expression for corticotrophin-releasing hormone receptors in prairie voles. Psychoneuroendocrinology 36:780-9
Pournajafi-Nazarloo, Hossein; Partoo, Leila; Sanzenbacher, Lisa et al. (2009) Social isolation modulates corticotropin-releasing factor type 2 receptor, urocortin 1 and urocortin 2 mRNAs expression in the cardiovascular system of prairie voles. Peptides 30:940-6
Ruscio, Michael G; Sweeny, Timothy D; Gomez, Adrian et al. (2009) Social environment alters central distribution of estrogen receptor alpha in juvenile prairie voles. Physiol Behav 98:296-301
Pournajafi-Nazarloo, Hossein; Partoo, Leila; Sanzenbacher, Lisa et al. (2009) Stress differentially modulates mRNA expression for corticotrophin-releasing hormone receptors in hypothalamus, hippocampus and pituitary of prairie voles. Neuropeptides 43:113-23
White-Traut, Rosemary; Watanabe, Kaoru; Pournajafi-Nazarloo, Hossein et al. (2009) Detection of salivary oxytocin levels in lactating women. Dev Psychobiol 51:367-73
Perry, Adam N; Paramadilok, Auratip; Cushing, Bruce S (2009) Neonatal oxytocin alters subsequent estrogen receptor alpha protein expression and estrogen sensitivity in the female rat. Behav Brain Res 205:154-61

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