Abstract

The overall objective of this core facility is to strengthen and expand the research efforts of Program Project investigators through the establishment of an efficient, cost-effective facility for cell and tissue acquisition and analysis. To achieve this goal, the Core proposes to: *Serve as a central facility for acquiring human placentas and harvesting placental cells, to include cytotrophoblasts and macrophages *Assist in the acquisition of leukocytes from mouse uterus *Perform characterization studies on human and rodent cells *Assist in storing and retrieving cells and cell lines *Perform quality control assessment of tissue culture reagents and cells *Serve as a training center in cell and tissue acquisition, characterizing and culture for Program Project personnel.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Program Projects (P01)
Project #
1P01HD039878-01A1
Application #
6593318
Study Section
Special Emphasis Panel (ZHD1)
Project Start
2002-05-02
Project End
2007-03-31
Budget Start
Budget End
Support Year
1
Fiscal Year
2002
Total Cost
Indirect Cost

  Institution

Name
University of Kansas
Department
Type
DUNS #
016060860
City
Kansas City
State
KS
Country
United States
Zip Code
66160

  Publications

Dai, Guoli; Bustamante, Juan J; Zou, Yuhong et al. (2011) Maternal hepatic growth response to pregnancy in the mouse. Exp Biol Med (Maywood) 236:1322-32
Mitra, Pallabi; Audus, Kenneth; Williams, Gervan et al. (2011) A comprehensive study demonstrating that p-glycoprotein function is directly affected by changes in pH: implications for intestinal pH and effects on drug absorption. J Pharm Sci 100:4258-68
Alam, S M Khorshed; Konno, Toshihiro; Rumi, M A Karim et al. (2010) Prolactin family of the guinea pig, Cavia porcellus. Endocrinology 151:3918-28
Mitra, Pallabi; Audus, Kenneth L (2010) MRP isoforms and BCRP mediate sulfate conjugate efflux out of BeWo cells. Int J Pharm 384:15-23
Kent, Lindsey N; Konno, Toshihiro; Soares, Michael J (2010) Phosphatidylinositol 3 kinase modulation of trophoblast cell differentiation. BMC Dev Biol 10:97
Mitra, Pallabi; Audus, Kenneth L (2009) Expression and functional activities of selected sulfotransferase isoforms in BeWo cells and primary cytotrophoblast cells. Biochem Pharmacol 78:1475-82
Alam, S M Khorshed; Konno, Toshihiro; Sahgal, Namita et al. (2008) Decidual cells produce a heparin-binding prolactin family cytokine with putative intrauterine regulatory actions. J Biol Chem 283:18957-68
Rytting, Erik; Audus, Kenneth L (2008) Contributions of phosphorylation to regulation of OCTN2 uptake of carnitine are minimal in BeWo cells. Biochem Pharmacol 75:745-51
Yu, Yang; Singh, Umashankar; Shi, Wei et al. (2008) Influence of murine maternal diabetes on placental morphology, gene expression, and function. Arch Physiol Biochem 114:99-110
Bustamante, Juan J; Dai, Guoli; Soares, Michael J (2008) Pregnancy and lactation modulate maternal splenic growth and development of the erythroid lineage in the rat and mouse. Reprod Fertil Dev 20:303-10

Showing the most recent 10 out of 57 publications