Abstract

This is a revision of Program Project proposal 1 PO1 HD-047609 'Gene-Environment Interactions in HumanParturition' that was submitted in October 2003, reviewed by an NICHD Special Emphasis Panel, and receiveda priority score of 199 (30th percentile). In this research program we proposed to identify the genef/c andenvironmental determinants of the length of human gestation/ timing of onset of spontaneous parturition, andto model the gene, environment, and maternal-fetal interactions that may underlie the risk of premature birthamong three racial/ ethnic populations: African-Americans, Hispanics and nonHispanic Whites.The previous review commented very favorably on all aspects of the Clinical Core as proposed, andnoted that a major advantage is the availability of the large clinical population, phenotype data that hasalready been collected, preliminary response analysis, preliminary study for DMA recovery, and superb facilities.This would enhance the efficacy of the proposed Program Project and also lead to a dramatic cost reduction.The review did not raise any concerns. The Core received a priority score of 100.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Program Projects (P01)
Project #
5P01HD047609-04
Application #
7707382
Study Section
Pediatrics Subcommittee (CHHD)
Project Start
2008-05-01
Project End
2010-04-30
Budget Start
2008-05-01
Budget End
2009-04-30
Support Year
4
Fiscal Year
2008
Total Cost
$142,507
Indirect Cost

  Institution

Name
University of California Irvine
Department
Type
DUNS #
046705849
City
Irvine
State
CA
Country
United States
Zip Code
92697

  Publications

Moog, Nora K; Buss, Claudia; Entringer, Sonja et al. (2016) Maternal Exposure to Childhood Trauma Is Associated During Pregnancy With Placental-Fetal Stress Physiology. Biol Psychiatry 79:831-839
Entringer, Sonja; Epel, Elissa S; Lin, Jue et al. (2015) Maternal estriol concentrations in early gestation predict infant telomere length. J Clin Endocrinol Metab 100:267-73
Entringer, Sonja; Epel, Elissa S; Lin, Jue et al. (2015) Maternal Folate Concentration in Early Pregnancy and Newborn Telomere Length. Ann Nutr Metab 66:202-8
Shalev, Idan; Entringer, Sonja; Wadhwa, Pathik D et al. (2013) Stress and telomere biology: a lifespan perspective. Psychoneuroendocrinology 38:1835-42
Entringer, Sonja; Epel, Elissa S; Lin, Jue et al. (2013) Maternal psychosocial stress during pregnancy is associated with newborn leukocyte telomere length. Am J Obstet Gynecol 208:134.e1-7
Entringer, Sonja; Wadhwa, Pathik D (2013) Developmental programming of obesity and metabolic dysfunction: role of prenatal stress and stress biology. Nestle Nutr Inst Workshop Ser 74:107-20
Entringer, Sonja; Buss, Claudia; Swanson, James M et al. (2012) Fetal programming of body composition, obesity, and metabolic function: the role of intrauterine stress and stress biology. J Nutr Metab 2012:632548
Wadhwa, Pathik D; Simhan, Hyagriv N; Entringer, Sonja et al. (2012) Variation in the maternal corticotrophin releasing hormone-binding protein (CRH-BP) gene and birth weight in Blacks, Hispanics and Whites. PLoS One 7:e43931
Wadhwa, Pathik D; Entringer, Sonja; Buss, Claudia et al. (2011) The contribution of maternal stress to preterm birth: issues and considerations. Clin Perinatol 38:351-84
Cammack, Alison L; Buss, Claudia; Entringer, Sonja et al. (2011) The association between early life adversity and bacterial vaginosis during pregnancy. Am J Obstet Gynecol 204:431.e1-8

Showing the most recent 10 out of 29 publications