Abstract

This scientific core with Dr. Schreiber as director will be responsible for services that are common to all projects within the program. All core services will be requested by requisition through Dr. Schreiber who will approve such requests. Centralization of these services will lead to both procedural efficiency as well as cost efficiency The core will be responsible for 1)isolation, culturing and distribution of cell cultures and reagent preparation for cell cultures 2) fixing, embedding, sectioning and mounting of cell and tissue samples 3) performing in situ hybridizations, and 4) assisting in developing transgenic/knock out mice. In addition, 5) confocal laser scanning microscopy (CLSM) which will be used by all projects, will be performed by the individual investigators but it will be paid for by the core which will also offer CLSM consulting services and 6) the core will play a major role in collaborative experiments between projects. Below, each core service is described a number including a brief description of core facilities and personnel, which are detailed further on the appropriate forms.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
2P01HL013262-25A1
Application #
6272496
Study Section
Project Start
1997-12-01
Project End
1998-11-30
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
25
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
Boston University
Department
Type
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02118

  Publications

Lucero, Héctor A; Mäki, Joni M; Kagan, Herbert M (2011) Activation of cellular chemotactic responses to chemokines coupled with oxidation of plasma membrane proteins by lysyl oxidase. J Neural Transm (Vienna) 118:1091-9
Chen, Hongjie; Koupenova, Milka; Yang, Dan et al. (2011) Regulation of MMP-9 expression by the A2b adenosine receptor and its dependency on TNF-? signaling. Exp Hematol 39:525-30
Yang, D; Chen, H; Koupenova, M et al. (2010) A new role for the A2b adenosine receptor in regulating platelet function. J Thromb Haemost 8:817-27
Grimsby, Jessica L; Lucero, Hector A; Trackman, Philip C et al. (2010) Role of lysyl oxidase propeptide in secretion and enzyme activity. J Cell Biochem 111:1231-43
St Hilaire, Cynthia; Carroll, Shannon H; Chen, Hongjie et al. (2009) Mechanisms of induction of adenosine receptor genes and its functional significance. J Cell Physiol 218:35-44
Wu, Xiaoyan; Kong, Xiaocen; Luchsinger, Larry et al. (2009) Regulating the activity of class II transactivator by posttranslational modifications: exploring the possibilities. Mol Cell Biol 29:5639-44
Chen, Hongjie; Yang, Dan; Carroll, Shannon H et al. (2009) Activation of the macrophage A2b adenosine receptor regulates tumor necrosis factor-alpha levels following vascular injury. Exp Hematol 37:533-8
Chandrasekharan, Bindu P; Kolachala, Vasantha L; Dalmasso, Guillaume et al. (2009) Adenosine 2B receptors (A(2B)AR) on enteric neurons regulate murine distal colonic motility. FASEB J 23:2727-34
Xu, Yong; Harton, Jonathan A; Smith, Barbara D (2008) CIITA mediates interferon-gamma repression of collagen transcription through phosphorylation-dependent interactions with co-repressor molecules. J Biol Chem 283:1243-56
St Hilaire, Cynthia; Yang, Dan; Schreiber, Barbara M et al. (2008) B-Myb regulates the A(2B) adenosine receptor in vascular smooth muscle cells. J Cell Biochem 103:1962-74

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