Abstract

This project develops new labeling techniques, generally applicable to the positron emitting radionuclides, oxygen-15, carbon-11 and fluorine-18 as well as developing new syntheses for compounds that will be used in the other research projects. In the current proposal several areas are emphasized. These are: 1. The synthesis of O-15 labeled DOPA. 2. New approaches to omega-labeling of compounds, particularly palmitic acid. 3. Approaches to synthesizing an improved marker of hypoxic tissue. 4. New approaches to synthesis of proteins with carbon-11 and fluorine-18. 5. New labeling techniques using F2. 6. Continued work on the fluorine-18-labeling of receptor ligands. 7. In vitro and in vivo evaluation of compounds developed in subsections 1 through 6.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL013851-34
Application #
6241487
Study Section
Project Start
1997-01-01
Project End
1998-06-30
Budget Start
1996-10-01
Budget End
1997-09-30
Support Year
34
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
Washington University
Department
Type
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130

  Publications

Peterson, Linda R; Herrero, Pilar; Coggan, Andrew R et al. (2015) Type 2 diabetes, obesity, and sex difference affect the fate of glucose in the human heart. Am J Physiol Heart Circ Physiol 308:H1510-6
Zhou, Dong; Chu, Wenhua; Xu, Jinbin et al. (2014) Synthesis, [¹?F] radiolabeling, and evaluation of poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors for in vivo imaging of PARP-1 using positron emission tomography. Bioorg Med Chem 22:1700-7
Gropler, Robert J (2014) Trying to prevent diabetic cardiovascular autonomic neuropathy: more questions than answers. J Nucl Cardiol 21:842-4
Lyons, Matthew R; Peterson, Linda R; McGill, Janet B et al. (2013) Impact of sex on the heart's metabolic and functional responses to diabetic therapies. Am J Physiol Heart Circ Physiol 305:H1584-91
Herrero, Pilar; Laforest, Richard; Shoghi, Kooresh et al. (2012) Feasibility and dosimetry studies for 18F-NOS as a potential PET radiopharmaceutical for inducible nitric oxide synthase in humans. J Nucl Med 53:994-1001
Gropler, Robert J (2012) The road connecting obesity and coronary vasomotor function: straight line or U-turn? JACC Cardiovasc Imaging 5:816-8
Solingapuram Sai, Kiran Kumar; Kil, Kun-Eek; Tu, Zhude et al. (2012) Synthesis, radiolabeling and initial in vivo evaluation of [(11)C]KSM-01 for imaging PPAR-? receptors. Bioorg Med Chem Lett 22:6233-6
Cheng, Ju-Chieh Kevin; Shoghi, Kooresh; Laforest, Richard (2012) Quantitative accuracy of MAP reconstruction for dynamic PET imaging in small animals. Med Phys 39:1029-41
Peterson, Linda R; Saeed, Ibrahim M; McGill, Janet B et al. (2012) Sex and type 2 diabetes: obesity-independent effects on left ventricular substrate metabolism and relaxation in humans. Obesity (Silver Spring) 20:802-10
Zhou, Dong; Chu, Wenhua; Dence, Carmen S et al. (2012) Highly efficient click labeling using 2-[¹?F]fluoroethyl azide and synthesis of an ¹?FN-hydroxysuccinimide ester as conjugation agent. Nucl Med Biol 39:1175-81

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