The Animal Core will provide support and funding for the animal related activities for Projects I, II and III. The creation of the Core is a direct response to the increased use of various rodent strains for in vivo studies of the molecular biology of tissue factor. The extensive use of transgenic and knockout animals (generated by other investigators and ourselves) demands careful breeding, documentation and genotyping of offspring. Currently, PAR-1-/-, Factor V Leiden, mTF+/- and transgenic and rescued mice containing the human TF minigene, and its derivatives, are maintained by the Core. The Core will be responsible for the maintenance of these and other lines, distribution of animals to the various projects and generating new lines by breeding and genotyping. The consolidation of all research animal support into a single Core to supervise the conduct of the specific approval protocols of the Program Project has been reviewed and approved by the institutional Animal Research Committee.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
2P01HL016411-26
Application #
6190521
Study Section
Project Start
1999-07-01
Project End
2000-05-31
Budget Start
Budget End
Support Year
26
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92037
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