The goal of this program-project is to better understand how the microcirculation creates and maintains an appropriate environment for the parenchymal cells. To achieve this goal we will study the fundamental processes of regulation and exchange in the microcirculation and certain inter-relationships between these two functions. A significant portion of the effort will be devoted to examining the behavior or individual microcirculatory vessels as well as the organized networks which they comprise. We will also examine the manner in which oxygen is delivered by the microcirculatory system to the parenchymal cells and the variations in tissue metabolism and oxygen delivery under different circumstances. We will also study the nature of the exchange barriers in the microcirculation for lipid-insoluble substances and the effect of these barriers in the microcirculation for lipid-insoluble substances and the effect of these barriers on the environment of the parenchymal cells. The program-project is being expanded substantially to add new studies on the function of the microcirculation at the cellular level. These studies are made possible by technical developments which enable us to examine questions of continuing interest to this project with new methods. By examining microcirculatory function at several levels as well as the interrelationships among separate functions we aim to achieve a better understanding of the manner in which the microcirculation supports normal parenchymal cell function. One of the distinguishing features of this program-project is the interdisciplinary nature of the research. The group has special expertise in the areas of physiology, engineering, applied mathematics, morphology and cell biology. At least two of these disciplines are represented in the typical project in the program-project. While the emphasis in the program is on the advancement of scientific understanding, we recognize that scientific advances are very dependent upon technological developments. Therefore, a portion of the activities of the program are directed to development of new instrumentation.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL017421-17
Application #
3097590
Study Section
Heart, Lung, and Blood Research Review Committee A (HLBA)
Project Start
1974-09-01
Project End
1994-08-31
Budget Start
1990-09-01
Budget End
1991-08-31
Support Year
17
Fiscal Year
1990
Total Cost
Indirect Cost
Name
University of Arizona
Department
Type
Schools of Medicine
DUNS #
City
Tucson
State
AZ
Country
United States
Zip Code
85721
Toth, Andras; Pal, Miklos; Intaglietta, Marcos et al. (2007) Contribution of anaerobic metabolism to reactive hyperemia in skeletal muscle. Am J Physiol Heart Circ Physiol 292:H2643-53
Richmond, K N; Shonat, R D; Lynch, R M et al. (1999) Critical PO(2) of skeletal muscle in vivo. Am J Physiol 277:H1831-40
Pal, M; Toth, A; Ping, P et al. (1998) Capillary blood flow and tissue metabolism in skeletal muscle during sympathetic trunk stimulation. Am J Physiol 274:H430-40
Shonat, R D; Johnson, P C (1997) Oxygen tension gradients and heterogeneity in venous microcirculation: a phosphorescence quenching study. Am J Physiol 272:H2233-40
Baldwin, A L; Wilson, L M; Gradus-Pizlo, I et al. (1997) Effect of atherosclerosis on transmural convection an arterial ultrastructure. Implications for local intravascular drug delivery. Arterioscler Thromb Vasc Biol 17:3365-75
Secomb, T W; Hsu, R (1996) Motion of red blood cells in capillaries with variable cross-sections. J Biomech Eng 118:538-44
Toth, A; Pal, M; Tischler, M E et al. (1996) Are there oxygen-deficient regions in resting skeletal muscle? Am J Physiol 270:H1933-9
Schubert, V; Schubert, P A; Breit, G et al. (1995) Analysis of arterial flowmotion in spinal cord injured and elderly subjects in an area at risk for the development of pressure sores. Paraplegia 33:387-97
Kerger, H; Torres Filho, I P; Rivas, M et al. (1995) Systemic and subcutaneous microvascular oxygen tension in conscious Syrian golden hamsters. Am J Physiol 268:H802-10
Secomb, T W (1995) Mechanics of blood flow in the microcirculation. Symp Soc Exp Biol 49:305-21

Showing the most recent 10 out of 101 publications