Abstract

Core B will support the projects in two major ways: a) preparation of transgenic mice; b) designing atherogenesis studies and performing qualitative and quantitative morphological and immunohistochemical analysis of mouse tissues including atherosclerotic lesions. Related to this, the core will assist Project in planning transgenesis and atherogenesis studies, and provide technical support in the genetic engineering of mice and analysis of their tissues. The core will also maintain and provide to the Projects various mice engineered by the Rubin Laboratory or created elsewhere, for planned atherogenic studies.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL018574-25
Application #
6353520
Study Section
Project Start
2000-09-30
Project End
2001-08-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
25
Fiscal Year
2000
Total Cost
$358,919
Indirect Cost

  Institution

Name
Lawrence Berkeley National Laboratory
Department
Type
DUNS #
078576738
City
Berkeley
State
CA
Country
United States
Zip Code
94720

  Publications

Ma, Ke; Forte, Trudy; Otvos, James D et al. (2005) Differential additive effects of endothelial lipase and scavenger receptor-class B type I on high-density lipoprotein metabolism in knockout mouse models. Arterioscler Thromb Vasc Biol 25:149-54
Kwiterovich Jr, Peter O; Cockrill, Steven L; Virgil, Donna G et al. (2005) A large high-density lipoprotein enriched in apolipoprotein C-I: a novel biochemical marker in infants of lower birth weight and younger gestational age. JAMA 293:1891-9
Dubrac, Sandrine; Lear, Steven R; Ananthanarayanan, Meena et al. (2005) Role of CYP27A in cholesterol and bile acid metabolism. J Lipid Res 46:76-85
Williams, Paul T; Blanche, Patricia J; Rawlings, Robin et al. (2005) Concordant lipoprotein and weight responses to dietary fat change in identical twins with divergent exercise levels 1. Am J Clin Nutr 82:181-7
Krauss, Ronald M (2005) Dietary and genetic probes of atherogenic dyslipidemia. Arterioscler Thromb Vasc Biol 25:2265-72
Badzioch, Michael D; Igo Jr, Robert P; Gagnon, France et al. (2004) Low-density lipoprotein particle size loci in familial combined hyperlipidemia: evidence for multiple loci from a genome scan. Arterioscler Thromb Vasc Biol 24:1942-50
Berneis, Kaspar; Shames, David M; Blanche, Patricia J et al. (2004) Plasma clearance of human low-density lipoprotein in human apolipoprotein B transgenic mice is related to particle diameter. Metabolism 53:483-7
Rizzo, Manfredi; Taylor, John M; Barbagallo, Carlo M et al. (2004) Effects on lipoprotein subclasses of combined expression of human hepatic lipase and human apoB in transgenic rabbits. Arterioscler Thromb Vasc Biol 24:141-6
Georgieva, A M; van Greevenbroek, M M J; Krauss, R M et al. (2004) Subclasses of low-density lipoprotein and very low-density lipoprotein in familial combined hyperlipidemia: relationship to multiple lipoprotein phenotype. Arterioscler Thromb Vasc Biol 24:744-9
Mar, Rebecca; Pajukanta, Paivi; Allayee, Hooman et al. (2004) Association of the APOLIPOPROTEIN A1/C3/A4/A5 gene cluster with triglyceride levels and LDL particle size in familial combined hyperlipidemia. Circ Res 94:993-9

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