Principal Investigator: Fisher. Aron B.CORE B- ADMINISTRATIVE UNITAron B. Fisher, M.D. abfifem Univ. of Pennsylvania Core LeaderABSTRACT Core B provides the administrative support for the general operations of the Program Project. Additionalgoals of the administrative core are to facilitate scientific interactions and communication among thecomponents of the Program Project, to coordinate review of scientific progress, and to provide regulatoryoversight. To achieve these goals, the core provides fiscal and secretarial support, coordinates researchseminars, work-in-progress meetings, and a cell and molecular biology journal club, schedules meetings of asteering committee and internal and external advisory boards, and prepares and supervises protocols foranimal use. The budget for the core represents 5.7% of the total direct costs for the Program Project.PHS 398/2590 (Rev.04/06) Page 332Number pages consecutively at the bottom throughout the application. Do not use suffixes such as 3a, 3b.CORE B PRINCIPAL Investigator/Program Director (Last, First, Middle): Fisher, Aron B. DETAILED BUDGET FOR INITIAL BUDGET PERIOD From Through DIRECT COSTS ONLY 07/01/07 06/30/08

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
2P01HL019737-31A1
Application #
7329977
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
2007-07-01
Project End
2012-06-30
Budget Start
2007-07-01
Budget End
2008-06-30
Support Year
31
Fiscal Year
2007
Total Cost
$114,655
Indirect Cost
Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Hawkins, Arie; Guttentag, Susan H; Deterding, Robin et al. (2015) A non-BRICHOS SFTPC mutant (SP-CI73T) linked to interstitial lung disease promotes a late block in macroautophagy disrupting cellular proteostasis and mitophagy. Am J Physiol Lung Cell Mol Physiol 308:L33-47
Chowdhury, Ibrul; Fisher, Aron B; Christofidou-Solomidou, Melpo et al. (2014) Keratinocyte growth factor and glucocorticoid induction of human peroxiredoxin 6 gene expression occur by independent mechanisms that are synergistic. Antioxid Redox Signal 20:391-402
Roszell, Blair R; Tao, Jian-Qin; Yu, Kevin J et al. (2013) Pulmonary abnormalities in animal models due to Niemann-Pick type C1 (NPC1) or C2 (NPC2) disease. PLoS One 8:e67084
Weibel, Ginny L; Joshi, Michelle R; Jerome, W Gray et al. (2012) Cytoskeleton disruption in J774 macrophages: consequences for lipid droplet formation and cholesterol flux. Biochim Biophys Acta 1821:464-72
Maguire, Jean Ann; Mulugeta, Surafel; Beers, Michael F (2012) Multiple ways to die: delineation of the unfolded protein response and apoptosis induced by Surfactant Protein C BRICHOS mutants. Int J Biochem Cell Biol 44:101-12
Roszell, Blair R; Tao, Jian-Qin; Yu, Kevin J et al. (2012) Characterization of the Niemann-Pick C pathway in alveolar type II cells and lamellar bodies of the lung. Am J Physiol Lung Cell Mol Physiol 302:L919-32
Rahaman, Hamidur; Zhou, Suiping; Dodia, Chandra et al. (2012) Increased phospholipase A2 activity with phosphorylation of peroxiredoxin 6 requires a conformational change in the protein. Biochemistry 51:5521-30
Maguire, Jean Ann; Mulugeta, Surafel; Beers, Michael F (2011) Endoplasmic reticulum stress induced by surfactant protein C BRICHOS mutants promotes proinflammatory signaling by epithelial cells. Am J Respir Cell Mol Biol 44:404-14
Beers, Michael F; Hawkins, Arie; Maguire, Jean Ann et al. (2011) A nonaggregating surfactant protein C mutant is misdirected to early endosomes and disrupts phospholipid recycling. Traffic 12:1196-210
Zhang, Linghui; Yu, Kevin; Robert, Kyle W et al. (2011) Rab38 targets to lamellar bodies and normalizes their sizes in lung alveolar type II epithelial cells. Am J Physiol Lung Cell Mol Physiol 301:L461-77

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