Principal Investigator: Fisher. Aron B.CORE B- ADMINISTRATIVE UNITAron B. Fisher, M.D. abfifem Univ. of Pennsylvania Core LeaderABSTRACT Core B provides the administrative support for the general operations of the Program Project. Additionalgoals of the administrative core are to facilitate scientific interactions and communication among thecomponents of the Program Project, to coordinate review of scientific progress, and to provide regulatoryoversight. To achieve these goals, the core provides fiscal and secretarial support, coordinates researchseminars, work-in-progress meetings, and a cell and molecular biology journal club, schedules meetings of asteering committee and internal and external advisory boards, and prepares and supervises protocols foranimal use. The budget for the core represents 5.7% of the total direct costs for the Program Project.PHS 398/2590 (Rev.04/06) Page 332Number pages consecutively at the bottom throughout the application. Do not use suffixes such as 3a, 3b.CORE B PRINCIPAL Investigator/Program Director (Last, First, Middle): Fisher, Aron B. DETAILED BUDGET FOR INITIAL BUDGET PERIOD From Through DIRECT COSTS ONLY 07/01/07 06/30/08

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
2P01HL019737-31A1
Application #
7329977
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
2007-07-01
Project End
2012-06-30
Budget Start
2007-07-01
Budget End
2008-06-30
Support Year
31
Fiscal Year
2007
Total Cost
$114,655
Indirect Cost
Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Hawkins, Arie; Guttentag, Susan H; Deterding, Robin et al. (2015) A non-BRICHOS SFTPC mutant (SP-CI73T) linked to interstitial lung disease promotes a late block in macroautophagy disrupting cellular proteostasis and mitophagy. Am J Physiol Lung Cell Mol Physiol 308:L33-47
Chowdhury, Ibrul; Fisher, Aron B; Christofidou-Solomidou, Melpo et al. (2014) Keratinocyte growth factor and glucocorticoid induction of human peroxiredoxin 6 gene expression occur by independent mechanisms that are synergistic. Antioxid Redox Signal 20:391-402
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Atochina-Vasserman, Elena N; Bates, Sandra R; Zhang, Peggy et al. (2011) Early alveolar epithelial dysfunction promotes lung inflammation in a mouse model of Hermansky-Pudlak syndrome. Am J Respir Crit Care Med 184:449-58
Zhong, Qian; Zhou, Beiyun; Ann, David K et al. (2011) Role of endoplasmic reticulum stress in epithelial-mesenchymal transition of alveolar epithelial cells: effects of misfolded surfactant protein. Am J Respir Cell Mol Biol 45:498-509
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