Abstract

The existing project is a controlled atherosclerosis regression trial using either niacin/colestipol or placebo in men who have had coronary artery bypass surgery. The endpoint is a computer derived comparison of averaged atherosclerosis in 5 cm. segments of femoral artery as seen by angiography at two year intervals. In reviewing the angiograms, it is obvious that the femoral disease is not extensive, but that lesions cluster at inner curvatures or branches. This supplemental application proposes an animal experiment to study the problem of lesion localization. Fourteen minipigs will be maintained on hypercholesterolemic diets and angiogrammed at five month intervals. The location and rate of progression of lesions will be studied. Following this, the animals will be sacrificed and flow replica castings made for hydrodynamic testing. The results of minipig and flow replica studies will be used to augment interpretation of the clinical trial by adding a lesion or lesion site specific measure of atherosclerosis to the segmental measure we now employ. The long-term goal is to develop an improved atherosclerosis endpoint measure for use in future human therapy trials.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL023619-09
Application #
3097844
Study Section
Heart, Lung, and Blood Research Review Committee B (HLBB)
Project Start
1979-07-01
Project End
1989-06-30
Budget Start
1987-07-01
Budget End
1988-06-30
Support Year
9
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
University of Southern California
Department
Type
Schools of Medicine
DUNS #
041544081
City
Los Angeles
State
CA
Country
United States
Zip Code
90033

  Publications

Selzer, R H; Hodis, H N; Kwong-Fu, H et al. (1994) Evaluation of computerized edge tracking for quantifying intima-media thickness of the common carotid artery from B-mode ultrasound images. Atherosclerosis 111:1-11
Blankenhorn, D H; Selzer, R H; Crawford, D W et al. (1993) Beneficial effects of colestipol-niacin therapy on the common carotid artery. Two- and four-year reduction of intima-media thickness measured by ultrasound. Circulation 88:20-8
Herrington, D M; Siebes, M; Walford, G D (1993) Sources of error in quantitative coronary angiography. Cathet Cardiovasc Diagn 29:314-21
Herrington, D M; Siebes, M; Sokol, D K et al. (1993) Variability in measures of coronary lumen dimensions using quantitative coronary angiography. J Am Coll Cardiol 22:1068-74
Hodis, H N; Quismorio Jr, F P; Wickham, E et al. (1993) The lipid, lipoprotein, and apolipoprotein effects of hydroxychloroquine in patients with systemic lupus erythematosus. J Rheumatol 20:661-5
Mack, W J; Blankenhorn, D H (1991) Factors influencing the formation of new human coronary lesions: age, blood pressure, and blood cholesterol. Am J Public Health 81:1180-4
Alaupovic, P; Blackenhorn, D H; Knight-Gibson, C et al. (1991) apoB-containing lipoprotein particles as risk factors for coronary artery disease. Adv Exp Med Biol 285:299-309
Hodis, H N; Amartey, J K; Crawford, D W et al. (1991) Relationship of arterial wall uptake of radiolabeled liposomes to the presence of monocyte/macrophage cells in the hypertensive and atherosclerotic arterial wall. Atherosclerosis 87:109-17
Hodis, H N; Amartey, J K; Crawford, D W et al. (1990) In vivo hypertensive arterial wall uptake of radiolabeled liposomes. Hypertension 15:600-5
Back, L H; Kwack, E Y; Crawford, D W (1990) Flow measurements in a model of the mildly curved femoral artery of man. Monogr Atheroscler 15:96-108

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