Abstract

This core (Core A) project will provide the resources necessary for the management and quantitative analysis of PET and NMR data collected in connection with all projects in the program project. Software support, including the mathematical and programming skills required for development, use and maintenance of software, will be provided by this core. Facilities provided by the core include existing Sun, Silicon Graphics workstations, Macintosh computers, and miscellaneous computer peripherals. Specific resources to be provided and the projects they support are: Data Acquisition (All Project); Image Reconstruction (Projects 1, 2, and 3); Volume of Interest Calculation (Projects 1 and 3) ; Kinetic Model Simulation and Parameter Estimation (Projects, 1, 3, 4 and 5); Model Development and Validation (Project 1,3,4, and 5); Experimental Design (Projects 1, 4, and 5); Statistical/Biostatistical Analysis (Project 1,4,and 5); Segmentation (Projects 1 and 3); Surface Tracking (Projects 1 and 3); Visualization (Project 1 and 3); Computing Support (All Projects)

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL025840-19
Application #
6312794
Study Section
Project Start
2000-05-01
Project End
2001-04-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
19
Fiscal Year
2000
Total Cost
$401,220
Indirect Cost

  Institution

Name
Lawrence Berkeley National Laboratory
Department
Type
DUNS #
078576738
City
Berkeley
State
CA
Country
United States
Zip Code
94720

  Publications

VanBrocklin, Henry F; Hanrahan, Stephen M; Enas, Joel D et al. (2007) Mitochondrial avid radioprobes. Preparation and evaluation of 7'(Z)-[125I]iodorotenone and 7'(Z)-[125I]iodorotenol. Nucl Med Biol 34:109-16
Maltz, Jonathan S; Budinger, Thomas F (2005) Evaluation of arterial endothelial function using transit times of artificially induced pulses. Physiol Meas 26:293-307
Marshall, Robert C; Powers-Risius, Patricia; Reutter, Bryan W et al. (2004) Kinetic analysis of 18F-fluorodihydrorotenone as a deposited myocardial flow tracer: comparison to 201Tl. J Nucl Med 45:1950-9
Sitek, Arkadiusz; Gullberg, Grant T; Huesman, Ronald H (2002) Correction for ambiguous solutions in factor analysis using a penalized least squares objective. IEEE Trans Med Imaging 21:216-25
Qi, Jinyi; Huesman, Ronald H (2002) Scatter correction for positron emission mammography. Phys Med Biol 47:2759-71
Klein, Gregory J; Huesman, Ronald H (2002) Four-dimensional processing of deformable cardiac PET data. Med Image Anal 6:29-46
Maltz, Jonathan S (2002) Parsimonious basis selection in exponential spectral analysis. Phys Med Biol 47:2341-65
Reutter, B W; Gullberg, G T; Huesman, R H (2002) Effects of temporal modelling on the statistical uncertainty of spatiotemporal distributions estimated directly from dynamic SPECT projections. Phys Med Biol 47:2673-83
Huber, J S; Moses, W W; Jones, W F et al. (2002) Effect of 176Lu background on singles transmission for LSO-based PET cameras. Phys Med Biol 47:3535-41
Marshall, R C; Powers-Risius, P; Reutter, B W et al. (2001) Kinetic analysis of 125I-iodorotenone as a deposited myocardial flow tracer: comparison with 99mTc-sestamibi. J Nucl Med 42:272-81

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