Abstract

The missions of the core are data collection and analyses, electrode fabrication and design, and electronics support. The consolidation of several functions into a single core and the assignment of the various required resources to this single core has lead to an increase in the responsibilities of the core, a diversity of personnel required to execute the mission of the core and a reasonable budget to meet these responsibilities. This core is essential to the efforts of Project which require extensive electrode, computer and electronic capabilities and a significant resource to Projects that routinely use this core for task- specific functions.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL027430-18
Application #
6302145
Study Section
Project Start
2000-04-01
Project End
2000-11-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
18
Fiscal Year
2000
Total Cost
$234,516
Indirect Cost

  Institution

Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599

  Publications

Cole, R T; Lucas, C L; Cascio, W E et al. (2005) A LabVIEW model incorporating an open-loop arterial impedance and a closed-loop circulatory system. Ann Biomed Eng 33:1555-73
Cascio, Wayne E; Yang, Hua; Muller-Borer, Barbara J et al. (2005) Ischemia-induced arrhythmia: the role of connexins, gap junctions, and attendant changes in impulse propagation. J Electrocardiol 38:55-9
Xu, Le; Meissner, Gerhard (2004) Mechanism of calmodulin inhibition of cardiac sarcoplasmic reticulum Ca2+ release channel (ryanodine receptor). Biophys J 86:797-804
Kim, Chang-Soo; Ufer, Stefan; Seagle, Christopher M et al. (2004) Use of micromachined probes for the recording of cardiac electrograms in isolated heart tissues. Biosens Bioelectron 19:1109-16
Graff, Ronald D; Kelley, Scott S; Lee, Greta M (2003) Role of pericellular matrix in development of a mechanically functional neocartilage. Biotechnol Bioeng 82:457-64
Stange, Mirko; Xu, Le; Balshaw, David et al. (2003) Characterization of recombinant skeletal muscle (Ser-2843) and cardiac muscle (Ser-2809) ryanodine receptor phosphorylation mutants. J Biol Chem 278:51693-702
Bidasee, Keshore R; Xu, Le; Meissner, Gerhard et al. (2003) Diketopyridylryanodine has three concentration-dependent effects on the cardiac calcium-release channel/ryanodine receptor. J Biol Chem 278:14237-48
Sun, Junhui; Xu, Le; Eu, Jerry P et al. (2003) Nitric oxide, NOC-12, and S-nitrosoglutathione modulate the skeletal muscle calcium release channel/ryanodine receptor by different mechanisms. An allosteric function for O2 in S-nitrosylation of the channel. J Biol Chem 278:8184-9
Yamaguchi, Naohiro; Xu, Le; Pasek, Daniel A et al. (2003) Molecular basis of calmodulin binding to cardiac muscle Ca(2+) release channel (ryanodine receptor). J Biol Chem 278:23480-6
Lemasters, John J; Qian, Ting; He, Lihua et al. (2002) Role of mitochondrial inner membrane permeabilization in necrotic cell death, apoptosis, and autophagy. Antioxid Redox Signal 4:769-81

Showing the most recent 10 out of 115 publications