The Protein Chemistry Core will provide the powerful tools of modem mass spectrometry to LPPG? investigators to permit structural identification and quantitation of HDL, SAA, PLTP and HDL-related? biomolecules. In addition to providing instrumental capabilities, Protein Chemistry Core staff will provide? consultation and collaboration on application of mass spectrometry to lipoprotein research, and this will? include development of new analytical methods targeted at achieving research objectives of LPPG? investigators. The Protein Chemistry Core will optimize the efficiency and cost-effectiveness through which? these services are provided LPPG investigators through a central laboratory. This avoids the need for LPPG? investigators to maintain the required instrumentation in their own laboratories and avoids the high cost of? commercial mass spectrometric services. By centralizing and standardizing procedures, the Protein Chemistry? Core will provide a common set of analytical tools that will lead to a unified understanding of molecular? mechanisms involved in lipoprotein metabolism and inflammation-related physiologic and pathophysiologic? processes in the artery wall.
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