Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL030616-17
Application #
6302188
Study Section
Project Start
2000-04-01
Project End
2001-03-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
17
Fiscal Year
2000
Total Cost
$255,781
Indirect Cost
Name
University of Rochester
Department
Type
DUNS #
208469486
City
Rochester
State
NY
Country
United States
Zip Code
14627
Sahni, Sanjeev K; Rydkina, Elena (2009) Host-cell interactions with pathogenic Rickettsia species. Future Microbiol 4:323-39
Sahni, Abha; Arévalo, Maria T; Sahni, Sanjeev K et al. (2009) The VE-cadherin binding domain of fibrinogen induces endothelial barrier permeability and enhances transendothelial migration of malignant breast epithelial cells. Int J Cancer 125:577-84
Sahni, Sanjeev K; Rydkina, Elena; Sahni, Abha (2008) The proteasome inhibitor MG132 induces nuclear translocation of erythroid transcription factor Nrf2 and cyclooxygenase-2 expression in human vascular endothelial cells. Thromb Res 122:820-5
Sahni, A; Simpson-Haidaris, P J; Sahni, S K et al. (2008) Fibrinogen synthesized by cancer cells augments the proliferative effect of fibroblast growth factor-2 (FGF-2). J Thromb Haemost 6:176-83
Mosesson, M W; Hernandez, I; Raife, T J et al. (2007) Plasma fibrinogen gamma'chain content in the thrombotic microangiopathy syndrome. J Thromb Haemost 5:62-9
Rydkina, Elena; Sahni, Abha; Baggs, Raymond B et al. (2006) Infection of human endothelial cells with spotted Fever group rickettsiae stimulates cyclooxygenase 2 expression and release of vasoactive prostaglandins. Infect Immun 74:5067-74
Sahni, Abha; Khorana, Alok A; Baggs, Raymond B et al. (2006) FGF-2 binding to fibrin(ogen) is required for augmented angiogenesis. Blood 107:126-31
Duan, Hai Ou; Simpson-Haidaris, Patricia J (2006) Cell type-specific differential induction of the human gamma-fibrinogen promoter by interleukin-6. J Biol Chem 281:12451-7
Rydkina, Elena; Silverman, David J; Sahni, Sanjeev K (2005) Activation of p38 stress-activated protein kinase during Rickettsia rickettsii infection of human endothelial cells: role in the induction of chemokine response. Cell Microbiol 7:1519-30
Clifton, Dawn R; Rydkina, Elena; Freeman, Robert S et al. (2005) NF-kappaB activation during Rickettsia rickettsii infection of endothelial cells involves the activation of catalytic IkappaB kinases IKKalpha and IKKbeta and phosphorylation-proteolysis of the inhibitor protein IkappaBalpha. Infect Immun 73:155-65

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