Abstract

The function of Core B will continue to be the breeding of inbred La Jolla SHR(LJ) and WKY(LJ) rats and providing all Program investigators with animals as needed. Core B will also be involved in breeding progeny for development of congenics derived from an SHR(LJ)xWKY(LJ) intercross and will provide the congenics to Project Investigators through Subcore C1.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
2P01HL035018-12
Application #
6272747
Study Section
Project Start
1998-07-01
Project End
1999-06-30
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
12
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
University of California San Diego
Department
Type
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093

  Publications

Harrall, Kylie K; Kechris, Katerina J; Tabakoff, Boris et al. (2016) Uncovering the liver's role in immunity through RNA co-expression networks. Mamm Genome 27:469-84
Saba, Laura M; Flink, Stephen C; Vanderlinden, Lauren A et al. (2015) The sequenced rat brain transcriptome--its use in identifying networks predisposing alcohol consumption. FEBS J 282:3556-78
Vanderlinden, Lauren A; Saba, Laura M; Printz, Morton P et al. (2014) Is the alcohol deprivation effect genetically mediated? Studies with HXB/BXH recombinant inbred rat strains. Alcohol Clin Exp Res 38:2148-57
Pravenec, Michal; Kozich, Viktor; Krijt, Jakub et al. (2013) Folate deficiency is associated with oxidative stress, increased blood pressure, and insulin resistance in spontaneously hypertensive rats. Am J Hypertens 26:135-40
Necká?, Jan; Šilhavy, Jan; Zídek, Václav et al. (2012) CD36 overexpression predisposes to arrhythmias but reduces infarct size in spontaneously hypertensive rats: gene expression profile analysis. Physiol Genomics 44:173-82
Houstek, Josef; Hejzlarova, Katerina; Vrbacky, Marek et al. (2012) Nonsynonymous variants in mt-Nd2, mt-Nd4, and mt-Nd5 are linked to effects on oxidative phosphorylation and insulin sensitivity in rat conplastic strains. Physiol Genomics 44:487-94
Pravenec, Michal; Zidek, Vaclav; Landa, Vladimir et al. (2011) Age-related autocrine diabetogenic effects of transgenic resistin in spontaneously hypertensive rats: gene expression profile analysis. Physiol Genomics 43:372-9
Wikoff, William R; Nagle, Megha A; Kouznetsova, Valentina L et al. (2011) Untargeted metabolomics identifies enterobiome metabolites and putative uremic toxins as substrates of organic anion transporter 1 (Oat1). J Proteome Res 10:2842-51
Malínská, Hana; Oliyarnyk, Olena; Hubová, Miriam et al. (2010) Increased liver oxidative stress and altered PUFA metabolism precede development of non-alcoholic steatohepatitis in SREBP-1a transgenic spontaneously hypertensive rats with genetic predisposition to hepatic steatosis. Mol Cell Biochem 335:119-25
Rosines, Eran; Johkura, Kohei; Zhang, Xing et al. (2010) Constructing kidney-like tissues from cells based on programs for organ development: toward a method of in vitro tissue engineering of the kidney. Tissue Eng Part A 16:2441-55

Showing the most recent 10 out of 187 publications