Abstract

This Core will continue to breed unique rat strains essential to the proposed studies of the Projects and which are available in the United States only from our colony. This Core will continue to breed and supply Program Investigators with the following strains: WKY/ Ij-cr, WKY/ Ij-tf, SHR/ Ij-cr, chromosome 2 congenics from a WKY/ Ij-cr X SHR/ Ij-cr cross, HXB-BXH Recombinant Inbred (RI) rat strains, SHR/Ola, BN.Lx, SHR.Lx and the PD/Cub rat. In addition, this Core will have responsibility for breeding additional intercross/backcross progeny or congenics as specified and requested by Projects. This Core will have oversight and review of all rat studies conducted in San Diego under this Program Project. This Core will assist Projects as requested and approved by the new Core B Advisory Committee.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL035018-20
Application #
7393845
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
2007-05-01
Project End
2008-04-30
Budget Start
2007-05-01
Budget End
2008-04-30
Support Year
20
Fiscal Year
2007
Total Cost
$506,650
Indirect Cost

  Institution

Name
University of California San Diego
Department
Type
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093

  Publications

Harrall, Kylie K; Kechris, Katerina J; Tabakoff, Boris et al. (2016) Uncovering the liver's role in immunity through RNA co-expression networks. Mamm Genome 27:469-84
Saba, Laura M; Flink, Stephen C; Vanderlinden, Lauren A et al. (2015) The sequenced rat brain transcriptome--its use in identifying networks predisposing alcohol consumption. FEBS J 282:3556-78
Vanderlinden, Lauren A; Saba, Laura M; Printz, Morton P et al. (2014) Is the alcohol deprivation effect genetically mediated? Studies with HXB/BXH recombinant inbred rat strains. Alcohol Clin Exp Res 38:2148-57
Pravenec, Michal; Kozich, Viktor; Krijt, Jakub et al. (2013) Folate deficiency is associated with oxidative stress, increased blood pressure, and insulin resistance in spontaneously hypertensive rats. Am J Hypertens 26:135-40
Necká?, Jan; Šilhavy, Jan; Zídek, Václav et al. (2012) CD36 overexpression predisposes to arrhythmias but reduces infarct size in spontaneously hypertensive rats: gene expression profile analysis. Physiol Genomics 44:173-82
Houstek, Josef; Hejzlarova, Katerina; Vrbacky, Marek et al. (2012) Nonsynonymous variants in mt-Nd2, mt-Nd4, and mt-Nd5 are linked to effects on oxidative phosphorylation and insulin sensitivity in rat conplastic strains. Physiol Genomics 44:487-94
Pravenec, Michal; Zidek, Vaclav; Landa, Vladimir et al. (2011) Age-related autocrine diabetogenic effects of transgenic resistin in spontaneously hypertensive rats: gene expression profile analysis. Physiol Genomics 43:372-9
Wikoff, William R; Nagle, Megha A; Kouznetsova, Valentina L et al. (2011) Untargeted metabolomics identifies enterobiome metabolites and putative uremic toxins as substrates of organic anion transporter 1 (Oat1). J Proteome Res 10:2842-51
Newman, Zachary L; Printz, Morton P; Liu, Shihui et al. (2010) Susceptibility to anthrax lethal toxin-induced rat death is controlled by a single chromosome 10 locus that includes rNlrp1. PLoS Pathog 6:e1000906
Malínská, Hana; Oliyarnyk, Olena; Hubová, Miriam et al. (2010) Increased liver oxidative stress and altered PUFA metabolism precede development of non-alcoholic steatohepatitis in SREBP-1a transgenic spontaneously hypertensive rats with genetic predisposition to hepatic steatosis. Mol Cell Biochem 335:119-25

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