Abstract

The proposed Clinical Core is designed with the objectives of: recruiting healthy controls and subjects; providing a central service for pulmonary function assessment, methacholine challenges, antigen skin testing, and bronchoprovocation; providing a central service for standardized collection of bronchoalveolar lavage fluid, for cellular analysis, and for distribution of samples to the investigators in Projects 1, 2, and 6; coordinating the retrieval and distribution of tissue specimens from patients receiving bronchial lung biopsies; and finally, providing quality control for the collection, computer entry, and storage of data.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL036577-07
Application #
3844517
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
7
Fiscal Year
1992
Total Cost
Indirect Cost

  Institution

Name
National Jewish Health
Department
Type
DUNS #
City
Denver
State
CO
Country
United States
Zip Code
80206

  Publications

Takeda, Katsuyuki; Webb, Tracy L; Ning, Fangkun et al. (2018) Mesenchymal Stem Cells Recruit CCR2+ Monocytes To Suppress Allergic Airway Inflammation. J Immunol 200:1261-1269
Wang, Meiqin; Yang, Ivana V; Davidson, Elizabeth J et al. (2018) Forkhead box protein 3 demethylation is associated with tolerance induction in peanut-induced intestinal allergy. J Allergy Clin Immunol 141:659-670.e2
Gelfand, Erwin W; Joetham, Anthony; Wang, Meiqin et al. (2017) Spectrum of T-lymphocyte activities regulating allergic lung inflammation. Immunol Rev 278:63-86
Gelfand, Erwin W (2017) Importance of the leukotriene B4-BLT1 and LTB4-BLT2 pathways in asthma. Semin Immunol 33:44-51
Takeda, Katsuyuki; Miyahara, Nobuaki; Matsubara, Shigeki et al. (2016) Immunomodulatory Effects of Ambroxol on Airway Hyperresponsiveness and Inflammation. Immune Netw 16:165-75
Schedel, Michaela; Jia, Yi; Michel, Sven et al. (2016) 1,25D3 prevents CD8(+)Tc2 skewing and asthma development through VDR binding changes to the Cyp11a1 promoter. Nat Commun 7:10213
Wang, M; Han, J; Domenico, J et al. (2016) Combined blockade of the histamine H1 and H4 receptor suppresses peanut-induced intestinal anaphylaxis by regulating dendritic cell function. Allergy 71:1561-1574
Goleva, Elena; Covar, Ronina; Martin, Richard J et al. (2016) Corticosteroid pharmacokinetic abnormalities in overweight and obese corticosteroid resistant asthmatics. J Allergy Clin Immunol Pract 4:357-60.e2
Medda, Rituparna; Lyros, Orestis; Schmidt, Jamie L et al. (2015) Anti inflammatory and anti angiogenic effect of black raspberry extract on human esophageal and intestinal microvascular endothelial cells. Microvasc Res 97:167-80
Li, Ling-Bo; Leung, Donald Y M; Goleva, Elena (2015) Activated p38 MAPK in Peripheral Blood Monocytes of Steroid Resistant Asthmatics. PLoS One 10:e0141909

Showing the most recent 10 out of 471 publications