The overall objective of the proposed research is to examine the synergistic effects of socioeconomic status (SES) and psychosocial risk factors (e.g., depression, hostility, social isolation) on biological and behavioral factors suspected or known to contribute to atherogenesis. Specifically, we proposed to test two hypotheses; first, that a factor-analytically defined psychosocial risk factor (PRF), defined by depression, hostility, and social isolation, is associated with increased stress-induced biological hyperactivity and risky health behaviors and, secondly, that SES moderates the strength of these relationships such, that among low SES individuals, the PRF is more strongly associated with stress-induced biological hyperreactivity and rksky health behaviors. In testing these two hypotheses, will assess various biological mechanisms that are suspected of directly or indirectly promoting and/or hastening atherosclerotic plaque development. The biological mechanisms to be assessed in this project include; a) behaviorally-induced cardiovascular responsivity; b) endocrine correlates of sympathetic nervous system (SNS) and hypothalamic-pituitary-adrenocortical (HPA) activation; c) hemostatic factors such as lipids, lipoproteins, and coagulation factor (fibrinogen), d) platelet activation factors (platelet factor 4, beta-thromboglobullin; and e) immune cytokines and adhesion molecule (ICAM) gene expression on circulating mononuclear phagocytes. If we find that PRF is more strongly associated with stress-indiced biological changes in low SES versus high SES individuals it will support our hypothesis that SES moderates the strength of the association between PRF and known or suspected pathogenic mechanisms. Given that the interaction between PRF and SES is the best predictor of all cause mortality in several studies, evidence for its association with pathogenic mechanisms of coronary heart disease (CHD) has significnt implications in our understanding of underlying biological mechanisms contributing to the relationship of SES, psychosocial factors, and CHD, as well as identifying potential areas of interventions.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
2P01HL036587-11
Application #
6272768
Study Section
Project Start
1998-08-01
Project End
1999-07-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
11
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Duke University
Department
Type
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705
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Ward-Caviness, Cavin K; Kraus, William E; Blach, Colette et al. (2018) Associations Between Residential Proximity to Traffic and Vascular Disease in a Cardiac Catheterization Cohort. Arterioscler Thromb Vasc Biol 38:275-282
Mirowsky, Jaime E; Devlin, Robert B; Diaz-Sanchez, David et al. (2017) A novel approach for measuring residential socioeconomic factors associated with cardiovascular and metabolic health. J Expo Sci Environ Epidemiol 27:281-289
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Jiang, Rong; Babyak, Michael A; Brummett, Beverly H et al. (2017) Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism interacts with gender to influence cortisol responses to mental stress. Psychoneuroendocrinology 79:13-19
Jiang, Rong; Babyak, Michael A; Brummett, Beverly H et al. (2017) Brain-derived neurotrophic factor rs6265 (Val66Met) polymorphism is associated with disease severity and incidence of cardiovascular events in a patient cohort. Am Heart J 190:40-45
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Ward-Caviness, Cavin K; Neas, Lucas M; Blach, Colette et al. (2016) Genetic Variants in the Bone Morphogenic Protein Gene Family Modify the Association between Residential Exposure to Traffic and Peripheral Arterial Disease. PLoS One 11:e0152670
McGarrah, Robert W; Craig, Damian M; Haynes, Carol et al. (2016) High-density lipoprotein subclass measurements improve mortality risk prediction, discrimination and reclassification in a cardiac catheterization cohort. Atherosclerosis 246:229-35
Ogle, Christin M; Rubin, David C; Siegler, Ilene C (2016) Accounting for Posttraumatic Stress Disorder Symptom Severity With Pre- and Posttrauma Measures: A Longitudinal Study of Older Adults. Clin Psychol Sci 4:272-286

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