Abstract

This project seeks to elucidate the functions in intact animals of specific extracellular matrix proteins and cell surface adhesion receptors. Particular attention will focus on fibronectin, its integrin receptors and the selectins. These proteins are thought to play important roles in development, including that of the heart and vascular system and in the interactions of circulating blood cells with the endothelial cells and basement membrane of the vessel wall. By generating mice with mutations in the genes encoding these adhesive proteins it will be possible to analyze their contributions to specific processes in vivo. The processes of most immediate interest to the overall aims of the Program of Excellence will be the focus of the research. These include development of the heart, cardiac defects, vasculogenesis, angiogenesis, hematopoiesis, lymphocyte and leukocyte traffic, various inflammatory responses including those involved in asthma and atherosclerosis as well as others.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL041484-12
Application #
6202272
Study Section
Project Start
1999-12-01
Project End
2001-11-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
12
Fiscal Year
2000
Total Cost
$755,192
Indirect Cost

  Institution

Name
Massachusetts Institute of Technology
Department
Type
DUNS #
001425594
City
Cambridge
State
MA
Country
United States
Zip Code
02139

  Publications

Lawrence, Roger; Yabe, Tomio; Hajmohammadi, Sassan et al. (2007) The principal neuronal gD-type 3-O-sulfotransferases and their products in central and peripheral nervous system tissues. Matrix Biol 26:442-55
Zannis, Vassilis I; Chroni, Angeliki; Krieger, Monty (2006) Role of apoA-I, ABCA1, LCAT, and SR-BI in the biogenesis of HDL. J Mol Med 84:276-94
Sugumaran, G; Elliott-Bryant, R; Phung, N et al. (2004) Characterization of splenic glycosaminoglycans accumulated in vivo in experimentally induced amyloid-susceptible and amyloid-resistant mice. Scand J Immunol 60:574-83
Singh, Purva; Reimer, Corinne L; Peters, John H et al. (2004) The spatial and temporal expression patterns of integrin alpha9beta1 and one of its ligands, the EIIIA segment of fibronectin, in cutaneous wound healing. J Invest Dermatol 123:1176-81
Panhuysen, C I M; Cupples, L A; Wilson, P W F et al. (2003) A genome scan for loci linked to quantitative insulin traits in persons without diabetes: the Framingham Offspring Study. Diabetologia 46:579-87
Gimeno, Ruth E; Ortegon, Angelica M; Patel, Shraddha et al. (2003) Characterization of a heart-specific fatty acid transport protein. J Biol Chem 278:16039-44
HajMohammadi, Sassan; Enjyoji, Keiichi; Princivalle, Marc et al. (2003) Normal levels of anticoagulant heparan sulfate are not essential for normal hemostasis. J Clin Invest 111:989-99
Kuberan, Balagurunathan; Beeler, David L; Lawrence, Roger et al. (2003) Rapid two-step synthesis of mitrin from heparosan: a replacement for heparin. J Am Chem Soc 125:12424-5
Kuberan, Balagurunathan; Beeler, David L; Lech, Miroslaw et al. (2003) Chemoenzymatic synthesis of classical and non-classical anticoagulant heparan sulfate polysaccharides. J Biol Chem 278:52613-21
Meigs, James B; Panhuysen, Carolien I M; Myers, Richard H et al. (2002) A genome-wide scan for loci linked to plasma levels of glucose and HbA(1c) in a community-based sample of Caucasian pedigrees: The Framingham Offspring Study. Diabetes 51:833-40

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