This application represents a renewal for our Program of Excellence in Molecular Biology of the Heart and Lung. This Program has as its goals 1) to initiate new research programs in the molecular biology of heart and lung, and 2) to provide exemplary training for postdoctoral fellows in utilizing molecular genetic techniques to understand development and function of the pulmonary and cardiovascular systems. The POEMB includes 11 scientific components applying shared techniques and experimental approaches to address critical issues of heart and lung development and function. These research programs are sharply focused in that they share common techniques and approaches, and the major emphasis is on several physiological systems that are critical to heart and lung function, i.e., ion transport, including pumps, channels and these stems. The programs are as follows: Na,K-ATPase and Cardiac Function, Molecular Mechanisms Determining lung Development and Disease, Renal Na+ Transporters in the Control of Arterial Blood Pressure. Mechanisms of Growth and Expression During Cardiac Development, Molecular Biology of Adrenergic Receptors; Heart and lung Developmental Genetics, Molecular Analysis of Cardiac Calcium Channels and Associated Proteins, Animal Models for Cardiovascular Disease. Role of Sodium Transporters in Regulation of human Blood Pressure. In addition, the Program supports several Cores; a Transgenic Mouse Core, which provides support for the construction of both transgenic and knock out mice, a DNA Core, which provides oligonucleotides and DNA sequencing services, and a Cell Culture and a Mouse Physiology Core which provides support for growing cells as well as helps underwrite the analysis of various heart functions in the mouse. A final core provides administrative support for the Program. Our Skills Development program includes centralized recruiting of postdoctoral fellows who pursue their research in the various laboratories of the POEMB. A seminar program is ongoing including both outside speakers and members of the Program where they present their ongoing research.
| Sadayappan, Sakthivel; Finley, Natosha; Howarth, Jack W et al. (2008) Role of the acidic N'region of cardiac troponin I in regulating myocardial function. FASEB J 22:1246-57 |
| Pattison, James Scott; Waggoner, Jason R; James, Jeanne et al. (2008) Phospholamban overexpression in transgenic rabbits. Transgenic Res 17:157-70 |
| Kalinichenko, Vladimir V; Gusarova, Galina A; Kim, Il-Man et al. (2004) Foxf1 haploinsufficiency reduces Notch-2 signaling during mouse lung development. Am J Physiol Lung Cell Mol Physiol 286:L521-30 |
| Small, Kersten M; McGraw, Dennis W; Liggett, Stephen B (2003) Pharmacology and physiology of human adrenergic receptor polymorphisms. Annu Rev Pharmacol Toxicol 43:381-411 |
| Sanbe, Atsushi; Gulick, James; Hanks, Mark C et al. (2003) Reengineering inducible cardiac-specific transgenesis with an attenuated myosin heavy chain promoter. Circ Res 92:609-16 |
| Liggett, Stephen B (2003) Polymorphisms of adrenergic receptors: variations on a theme. Assay Drug Dev Technol 1:317-26 |
| Golovina, Vera A; Song, Hong; James, Paul F et al. (2003) Na+ pump alpha 2-subunit expression modulates Ca2+ signaling. Am J Physiol Cell Physiol 284:C475-86 |
| Kalinichenko, Vladimir V; Zhou, Yan; Shin, Brian et al. (2002) Wild-type levels of the mouse Forkhead Box f1 gene are essential for lung repair. Am J Physiol Lung Cell Mol Physiol 282:L1253-65 |
| Whitsett, Jeffrey A; Clark, Jean C; Picard, Lara et al. (2002) Fibroblast growth factor 18 influences proximal programming during lung morphogenesis. J Biol Chem 277:22743-9 |
| Lim, Lorena; Kalinichenko, Vladimir V; Whitsett, Jeffrey A et al. (2002) Fusion of lung lobes and vessels in mouse embryos heterozygous for the forkhead box f1 targeted allele. Am J Physiol Lung Cell Mol Physiol 282:L1012-22 |
Showing the most recent 10 out of 257 publications
