Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL041633-09
Application #
6242040
Study Section
Project Start
1997-02-01
Project End
1998-01-31
Budget Start
1996-10-01
Budget End
1997-09-30
Support Year
9
Fiscal Year
1997
Total Cost
Indirect Cost
Name
J. David Gladstone Institutes
Department
Type
DUNS #
047120084
City
San Francisco
State
CA
Country
United States
Zip Code
94158
Svensson, Annika W; Casey, Patrick J; Young, Stephen G et al. (2006) Genetic and pharmacologic analyses of the role of Icmt in Ras membrane association and function. Methods Enzymol 407:144-59
Ruiz, Jose; Kouiavskaia, Diana; Migliorini, Molly et al. (2005) The apoE isoform binding properties of the VLDL receptor reveal marked differences from LRP and the LDL receptor. J Lipid Res 46:1721-31
Sauer, Ines; Dunay, Ildiko R; Weisgraber, Karl et al. (2005) An apolipoprotein E-derived peptide mediates uptake of sterically stabilized liposomes into brain capillary endothelial cells. Biochemistry 44:2021-9
Kasravi, F Behzad; Lee, Diana H; Weisgraber, Karl et al. (2005) Lipoprotein-bound endotoxin exerts an immunomodulatory effect on hepatocytes through the lipid A domain of LPS. J Endotoxin Res 11:19-24
Schneider, Matthias; Witztum, Joseph L; Young, Stephen G et al. (2005) High-level lipoprotein [a] expression in transgenic mice: evidence for oxidized phospholipids in lipoprotein [a] but not in low density lipoproteins. J Lipid Res 46:769-78
Bergo, Martin O; Gavino, Bryant J; Hong, Christine et al. (2004) Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf. J Clin Invest 113:539-50
Bergo, Martin O; Lieu, Hsiao D; Gavino, Bryant J et al. (2004) On the physiological importance of endoproteolysis of CAAX proteins: heart-specific RCE1 knockout mice develop a lethal cardiomyopathy. J Biol Chem 279:4729-36
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Raffai, Robert L; McPherson, Ruth; Weisgraber, Karl H et al. (2003) Antibody phenotyping test for the human apolipoprotein E2 isoform. Clin Chem 49:1524-6
Liao, Wei; Hui, To Y; Young, Stephen G et al. (2003) Blocking microsomal triglyceride transfer protein interferes with apoB secretion without causing retention or stress in the ER. J Lipid Res 44:978-85

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