Abstract

The Animal Model Core will generate transgenic and gene-targeted mice and will provide for the care and maintenance of all mouse models. In addition, the Core will be responsible for generating human apo-B transgenic rabbits. Each of the projects in the Program Project uses one or more animal models, and the centralization of all animal activities within this Core will result in the most efficient use of resources.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL041633-12
Application #
6314124
Study Section
Project Start
2000-02-01
Project End
2001-01-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
12
Fiscal Year
2000
Total Cost
$570,626
Indirect Cost

  Institution

Name
J. David Gladstone Institutes
Department
Type
DUNS #
047120084
City
San Francisco
State
CA
Country
United States
Zip Code
94158

  Publications

Svensson, Annika W; Casey, Patrick J; Young, Stephen G et al. (2006) Genetic and pharmacologic analyses of the role of Icmt in Ras membrane association and function. Methods Enzymol 407:144-59
Sauer, Ines; Dunay, Ildiko R; Weisgraber, Karl et al. (2005) An apolipoprotein E-derived peptide mediates uptake of sterically stabilized liposomes into brain capillary endothelial cells. Biochemistry 44:2021-9
Kasravi, F Behzad; Lee, Diana H; Weisgraber, Karl et al. (2005) Lipoprotein-bound endotoxin exerts an immunomodulatory effect on hepatocytes through the lipid A domain of LPS. J Endotoxin Res 11:19-24
Schneider, Matthias; Witztum, Joseph L; Young, Stephen G et al. (2005) High-level lipoprotein [a] expression in transgenic mice: evidence for oxidized phospholipids in lipoprotein [a] but not in low density lipoproteins. J Lipid Res 46:769-78
Ruiz, Jose; Kouiavskaia, Diana; Migliorini, Molly et al. (2005) The apoE isoform binding properties of the VLDL receptor reveal marked differences from LRP and the LDL receptor. J Lipid Res 46:1721-31
Bergo, Martin O; Gavino, Bryant J; Hong, Christine et al. (2004) Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf. J Clin Invest 113:539-50
Bergo, Martin O; Lieu, Hsiao D; Gavino, Bryant J et al. (2004) On the physiological importance of endoproteolysis of CAAX proteins: heart-specific RCE1 knockout mice develop a lethal cardiomyopathy. J Biol Chem 279:4729-36
Raffai, Robert L; Weisgraber, Karl H (2003) Cholesterol: from heart attacks to Alzheimer's disease. J Lipid Res 44:1423-30
Raffai, Robert L; McPherson, Ruth; Weisgraber, Karl H et al. (2003) Antibody phenotyping test for the human apolipoprotein E2 isoform. Clin Chem 49:1524-6
Liao, Wei; Hui, To Y; Young, Stephen G et al. (2003) Blocking microsomal triglyceride transfer protein interferes with apoB secretion without causing retention or stress in the ER. J Lipid Res 44:978-85

Showing the most recent 10 out of 168 publications