The overall objective of our Program Project Grant is to characterize the cellular and molecular events which mediate the intense inflammatory response that occurs rapidly upon reperfusion of the previously ischemic myocardium. This inflammatory response represents a classic reaction to injury and substantial evidence suggests that it may extend cardiac injury. The three projects of this Program Project Grant all are directed at characterizing the cellular and molecular events that control adhesion molecule induction, expression, activation, and adhesion molecule mediated cellular events. Adhesion molecules govern and control leukocyte trafficking, leukocyte secretion and leukocyte mediated injury and the understanding of their metabolism is critical to the understanding of the inflammatory reaction to injury ensuing from reperfusion. Project 1 utilizes a chronic animal model of ischemia and reperfusion in which the cardiac lymph duct can be cannulated to allow access to cardiac extracellular fluid in animals in whom there is no surgical trauma. The role, induction, and activation of adhesion molecules is studied by measurements of leukocyte flux, immuno- cytochemistry, in situ hybridization, and quantitative Northern blotting. Project 2 takes advantage of a newly developed mouse model of ischemia and reperfusion and is designed to study the consequence of genetic deletion of specific adhesion molecules, chemotactic agents and chemotactic receptors. Molecular and cellular consequences of gene deletion are studied. Project 3 deals with the cellular and molecular mechanisms by which individual adhesion molecules control leukocyte trafficking, leukocyte secretion, and leukocyte induced cardiac injury.
| Mann, Douglas L (2014) Colchicine and the failing heart: a ""FINER"" anti-inflammatory agent? JACC Heart Fail 2:138-40 |
| Burns, Alan R; Phillips, Sharon C; Sokoya, Elke M (2012) Pannexin protein expression in the rat middle cerebral artery. J Vasc Res 49:101-10 |
| Mann, Douglas L (2012) Sphingosine 1-phosphate as a therapeutic target in heart failure: more questions than answers. Circulation 125:2692-4 |
| Hartley, Craig J; Reddy, Anilkumar K; Madala, Sridhar et al. (2011) Doppler velocity measurements from large and small arteries of mice. Am J Physiol Heart Circ Physiol 301:H269-78 |
| Hartley, Craig J; Reddy, Anilkumar K; Madala, Sridhar et al. (2010) Feasibility of dual Doppler velocity measurements to estimate volume pulsations of an arterial segment. Ultrasound Med Biol 36:1169-75 |
| Haudek, Sandra B; Gupta, Damon; Dewald, Oliver et al. (2009) Rho kinase-1 mediates cardiac fibrosis by regulating fibroblast precursor cell differentiation. Cardiovasc Res 83:511-8 |
| Reddy, Anilkumar K; Namiranian, Khodidad; Lloyd, Eric E et al. (2009) Effect of isoflurane on aortic impedance in mice. Conf Proc IEEE Eng Med Biol Soc 2009:1104-5 |
| Divakaran, Vijay; Adrogue, Julia; Ishiyama, Masakuni et al. (2009) Adaptive and maladptive effects of SMAD3 signaling in the adult heart after hemodynamic pressure overloading. Circ Heart Fail 2:633-42 |
| Wu, Huaizhu; Gower, R Michael; Wang, Hong et al. (2009) Functional role of CD11c+ monocytes in atherogenesis associated with hypercholesterolemia. Circulation 119:2708-17 |
| Liu, Xiuping; Zuo, Yumei; Zhang, Weina et al. (2009) Expression of interleukin-15 and its receptor on the surface of stimulated human umbilical vein endothelial cells. J Huazhong Univ Sci Technolog Med Sci 29:527-34 |
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