The Cytogenetics Core is of major significance to the success of Projects 1,2, 3 and the Core C Repository. Its expertise draws on 32 years of experience of the Research and Clinical Cytogenetics Laboratories at Oregon Health Sciences University. These laboratories are recognized internationally for the highest standards of academic cytogenetics excellence. Together, they have a staff of 14 technologists and research associates studying approximately 2,500 blood, bone marrow, solid tumor, amniotic fluid, chorionic villus and other solid tissue samples annually. Through their early efforts of test development, and more recently as the Cytogenetics Core for the current program project grant, these combined laboratories have become a national resource for Fanconi anemia testing.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL048546-07
Application #
6338873
Study Section
Project Start
2000-08-01
Project End
2001-06-30
Budget Start
Budget End
Support Year
7
Fiscal Year
2000
Total Cost
$314,458
Indirect Cost
Name
Oregon Health and Science University
Department
Type
DUNS #
009584210
City
Portland
State
OR
Country
United States
Zip Code
97239
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Kroeger Jr, Paul T; Drummond, Bridgette E; Miceli, Rachel et al. (2017) The zebrafish kidney mutant zeppelin reveals that brca2/fancd1 is essential for pronephros development. Dev Biol 428:148-163
Rondinelli, Beatrice; Gogola, Ewa; YĆ¼cel, Hatice et al. (2017) EZH2 promotes degradation of stalled replication forks by recruiting MUS81 through histone H3 trimethylation. Nat Cell Biol 19:1371-1378
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Zhang, Qing-Shuo; Tang, Weiliang; Deater, Matthew et al. (2016) Metformin improves defective hematopoiesis and delays tumor formation in Fanconi anemia mice. Blood 128:2774-2784
Zhang, Haojian; Kozono, David E; O'Connor, Kevin W et al. (2016) TGF-? Inhibition Rescues Hematopoietic Stem Cell Defects and Bone Marrow Failure in Fanconi Anemia. Cell Stem Cell 18:668-81
Zhang, Qing-Shuo; Benedetti, Eric; Deater, Matthew et al. (2015) Oxymetholone therapy of fanconi anemia suppresses osteopontin transcription and induces hematopoietic stem cell cycling. Stem Cell Reports 4:90-102
Lombardi, Anne J; Hoskins, Elizabeth E; Foglesong, Grant D et al. (2015) Acquisition of Relative Interstrand Crosslinker Resistance and PARP Inhibitor Sensitivity in Fanconi Anemia Head and Neck Cancers. Clin Cancer Res 21:1962-72

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