Abstract

Each of the projects include as a component the design, study, or use of gene targeted as well as normal mice or mouse tissues.
The aim of the core is to centralize and coordinate these activities, with streamlined generation of gene targeted chimeras, generation of mutant stocks, and histological analysis of mutant tissues. In this way all techniques relating to ES cell work, mouse stock maintenance, and tissue harvesting and analysis will be performed by a small number of people using standardized methods, under the supervision of a PI with specific experience in the field.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL048728-11
Application #
6644989
Study Section
Project Start
2002-09-01
Project End
2003-08-31
Budget Start
Budget End
Support Year
11
Fiscal Year
2002
Total Cost
Indirect Cost

  Institution

Name
Scripps Research Institute
Department
Type
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92037

  Publications

Cantor, Joseph M; Rose, David M; Slepak, Marina et al. (2015) Fine-tuning Tumor Immunity with Integrin Trans-regulation. Cancer Immunol Res 3:661-7
Estrach, Soline; Lee, Sin-Ae; Boulter, Etienne et al. (2014) CD98hc (SLC3A2) loss protects against ras-driven tumorigenesis by modulating integrin-mediated mechanotransduction. Cancer Res 74:6878-89
Kim, Chungho; Ye, Feng; Ginsberg, Mark H (2011) Regulation of integrin activation. Annu Rev Cell Dev Biol 27:321-45
Tzima, Ellie; Schimmel, Paul (2006) Inhibition of tumor angiogenesis by a natural fragment of a tRNA synthetase. Trends Biochem Sci 31:7-10
Goto, Shinya; Tamura, Noriko; Ishida, Hideyuki et al. (2006) Dependence of platelet thrombus stability on sustained glycoprotein IIb/IIIa activation through adenosine 5'-diphosphate receptor stimulation and cyclic calcium signaling. J Am Coll Cardiol 47:155-62
Tzima, Eleni; Reader, John S; Irani-Tehrani, Mohamad et al. (2005) VE-cadherin links tRNA synthetase cytokine to anti-angiogenic function. J Biol Chem 280:2405-8
Kloeker, Susanne; Major, Michael B; Calderwood, David A et al. (2004) The Kindler syndrome protein is regulated by transforming growth factor-beta and involved in integrin-mediated adhesion. J Biol Chem 279:6824-33
Kasirer-Friede, Ana; Cozzi, Maria Rita; Mazzucato, Mario et al. (2004) Signaling through GP Ib-IX-V activates alpha IIb beta 3 independently of other receptors. Blood 103:3403-11
Federici, Augusto B; Canciani, Maria T; Forza, Ileana et al. (2004) A sensitive ristocetin co-factor activity assay with recombinant glycoprotein Ibalpha for the diagnosis of patients with low von Willebrand factor levels. Haematologica 89:77-85
Mazzucato, Mario; Cozzi, Maria Rita; Pradella, Paola et al. (2004) Distinct roles of ADP receptors in von Willebrand factor-mediated platelet signaling and activation under high flow. Blood 104:3221-7

Showing the most recent 10 out of 142 publications