Abstract

The morphology core, housed in the department of cell biology and anatomy, will provide to the Program Project the resources of a state-of-the-art otics laboratory and histology laboratory. Routine light microscopy, transmission and scanning electron microscopy and epifluorescence and confocal microscopy are available. This faculty, and the expertise of the individual that run it, will provide to the Program Project the cell and histologic support that is critical to any gene therapy program.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL051746-04
Application #
5214114
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost

  Publications

Ryan, Dorothy M; Vincent, Thomas L; Salit, Jacqueline et al. (2014) Smoking dysregulates the human airway basal cell transcriptome at COPD risk locus 19q13.2. PLoS One 9:e88051
Dvorak, Anna; Tilley, Ann E; Shaykhiev, Renat et al. (2011) Do airway epithelium air-liquid cultures represent the in vivo airway epithelium transcriptome? Am J Respir Cell Mol Biol 44:465-73
Krause, Anja; Whu, Wen Zhu; Xu, Yaqin et al. (2011) Protective anti-Pseudomonas aeruginosa humoral and cellular mucosal immunity by AdC7-mediated expression of the P. aeruginosa protein OprF. Vaccine 29:2131-9
Limberis, Maria P; Bell, Christie L; Heath, Jack et al. (2010) Activation of transgene-specific T cells following lentivirus-mediated gene delivery to mouse lung. Mol Ther 18:143-50
Song, Yuhu; Lou, Howard H; Boyer, Julie L et al. (2009) Functional cystic fibrosis transmembrane conductance regulator expression in cystic fibrosis airway epithelial cells by AAV6.2-mediated segmental trans-splicing. Hum Gene Ther 20:267-81
Vandenberghe, L H; Breous, E; Nam, H-J et al. (2009) Naturally occurring singleton residues in AAV capsid impact vector performance and illustrate structural constraints. Gene Ther 16:1416-28
Fein, David E; Limberis, Maria P; Maloney, Sean F et al. (2009) Cationic lipid formulations alter the in vivo tropism of AAV2/9 vector in lung. Mol Ther 17:2078-87
Limberis, Maria P; Vandenberghe, Luk H; Zhang, Liqun et al. (2009) Transduction efficiencies of novel AAV vectors in mouse airway epithelium in vivo and human ciliated airway epithelium in vitro. Mol Ther 17:294-301
Tertilt, Christine; Joh, Ju; Krause, Anja et al. (2009) Expression of B-cell activating factor enhances protective immunity of a vaccine against Pseudomonas aeruginosa. Infect Immun 77:3044-55
Limberis, M P; Bell, C L; Wilson, J M (2009) Identification of the murine firefly luciferase-specific CD8 T-cell epitopes. Gene Ther 16:441-7

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