Abstract

This Core provides computer, electronics, instrumentation and machine shop support services to the Program Project Gram Investigators. The services are an essemial part of the Projects' protocol design, animal maintenance, data acquisition and data analyses. Specific services range from creating instrumentation for acute and chronic animal experimemation to managing a World Wide Web server, to precision machining of custom mechanical parts. The personnel in this core are responsible for developing and implementing advances in microcomputer technology and software, and for developing new instrumentation to meet the research needs of the Program Project. Instrumentation and computer technologies developed by the various investigators are made available to all members of the Program Project team. Imaging support for immunohistochemical, densitometic, morphometric, and stereological analyses has been added by the Core during the previous grant period by the various projects as required for their experimental protocols. The Core will continue to increase the support for histological and immunohistochemical analyses during the next funding period. The Core will continue to support the development and use of mathematical modeling to as a quantitative way to test new and integrative physiological concepts.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL051971-13
Application #
7163819
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
Budget Start
2005-12-01
Budget End
2006-11-30
Support Year
13
Fiscal Year
2006
Total Cost
$134,005
Indirect Cost

  Institution

Name
University of Mississippi Medical Center
Department
Type
DUNS #
928824473
City
Jackson
State
MS
Country
United States
Zip Code
39216

  Publications

Faulkner, Jessica L; Plenty, Nicole L; Wallace, Kedra et al. (2018) Selective inhibition of 20-hydroxyeicosatetraenoic acid lowers blood pressure in a rat model of preeclampsia. Prostaglandins Other Lipid Mediat 134:108-113
Spann, Redin A; Lawson, William J; Bidwell 3rd, Gene L et al. (2018) Rodent vertical sleeve gastrectomy alters maternal immune health and fetoplacental development. Clin Sci (Lond) 132:295-312
Lindsey, Merry L; Jung, Mira; Hall, Michael E et al. (2018) Proteomic analysis of the cardiac extracellular matrix: clinical research applications. Expert Rev Proteomics 15:105-112
Mouton, Alan J; Rivera Gonzalez, Osvaldo J; Kaminski, Amanda R et al. (2018) Matrix metalloproteinase-12 as an endogenous resolution promoting factor following myocardial infarction. Pharmacol Res 137:252-258
Cates, Courtney; Rousselle, Thomas; Wang, Jinli et al. (2018) Activated protein C protects against pressure overload-induced hypertrophy through AMPK signaling. Biochem Biophys Res Commun 495:2584-2594
do Carmo, Jussara M; da Silva, Alexandre A; Moak, Sydney P et al. (2018) Increased sleep time and reduced energy expenditure contribute to obesity after ovariectomy and a high fat diet. Life Sci 212:119-128
Taylor, Erin B; Barati, Michelle T; Powell, David W et al. (2018) Plasma Cell Depletion Attenuates Hypertension in an Experimental Model of Autoimmune Disease. Hypertension 71:719-728
Lindsey, Merry L (2018) Assigning matrix metalloproteinase roles in ischaemic cardiac remodelling. Nat Rev Cardiol 15:471-479
Wang, Lin; Quan, Nanhu; Sun, Wanqing et al. (2018) Cardiomyocyte-specific deletion of Sirt1 gene sensitizes myocardium to ischaemia and reperfusion injury. Cardiovasc Res 114:805-821
do Carmo, Jussara M; da Silva, Alexandre A; Freeman, John Nathan et al. (2018) Neuronal Suppressor of Cytokine Signaling 3: Role in Modulating Chronic Metabolic and Cardiovascular Effects of Leptin. Hypertension 71:1248-1257

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