Abstract

This core will continue to be responsible for the coordination of the activities among component Projects and Cores. Core A will also be responsible for maintaining budgets, purchasing and procurement matters related to conducting the research proposed in the program. In addition, Core A, in consultation with the PPG Executive Committee, will continue to administer PPG training activities. As outlined in the progress report below, a substantial number of students and postdoctoral fellows have received research training in cardiovascular biology in the laboratories of the Projects and Cores of this Program. This is an important source of synergy in our program and of great importance to us because of the future impact to be provided by these outstanding trainees. Core A will also continue to schedule meetings and seminars for the PPG group and provide secretarial support for the various Projects and Cores.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL052490-15
Application #
8114789
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
2012-12-31
Budget Start
2010-01-01
Budget End
2012-12-31
Support Year
15
Fiscal Year
2010
Total Cost
$215,728
Indirect Cost

  Institution

Name
University of Missouri-Columbia
Department
Type
DUNS #
153890272
City
Columbia
State
MO
Country
United States
Zip Code
65211

  Publications

Masseau, I; Bowles, D K (2015) Carotid Endothelial VCAM-1 Is an Early Marker of Carotid Atherosclerosis and Predicts Coronary Artery Disease in Swine. J Biomed Sci Eng 8:789-796
Gole, Hope K A; Tharp, Darla L; Bowles, Douglas K (2014) Upregulation of intermediate-conductance Ca2+-activated K+ channels (KCNN4) in porcine coronary smooth muscle requires NADPH oxidase 5 (NOX5). PLoS One 9:e105337
McKenney, Mikaela L; Schultz, Kyle A; Boyd, Jack H et al. (2014) Epicardial adipose excision slows the progression of porcine coronary atherosclerosis. J Cardiothorac Surg 9:2
Heaps, Cristine L; Robles, Juan Carlos; Sarin, Vandana et al. (2014) Exercise training-induced adaptations in mediators of sustained endothelium-dependent coronary artery relaxation in a porcine model of ischemic heart disease. Microcirculation 21:388-400
Hamilton, Marc T; Hamilton, Deborah G; Zderic, Theodore W (2014) Sedentary behavior as a mediator of type 2 diabetes. Med Sport Sci 60:11-26
Bender, Shawn B; de Beer, Vincent J; Tharp, Darla L et al. (2014) Reduced contribution of endothelin to the regulation of systemic and pulmonary vascular tone in severe familial hypercholesterolaemia. J Physiol 592:1757-69
Simmons, Grant H; Padilla, Jaume; Jenkins, Nathan T et al. (2014) Exercise training and vascular cell phenotype in a swine model of familial hypercholesterolaemia: conduit arteries and veins. Exp Physiol 99:454-65
Fain, John N; Company, Joseph M; Booth, Frank W et al. (2013) Exercise training does not increase muscle FNDC5 protein or mRNA expression in pigs. Metabolism 62:1503-11
de Beer, Vincent J; Merkus, Daphne; Bender, Shawn B et al. (2013) Familial hypercholesterolemia impairs exercise-induced systemic vasodilation due to reduced NO bioavailability. J Appl Physiol (1985) 115:1767-76
Congdon, Kimberly A; Hammond, Ashley S; Ravosa, Matthew J (2012) Differential limb loading in miniature pigs (Sus scrofa domesticus): a test of chondral modeling theory. J Exp Biol 215:1472-83

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