Abstract

This Core A (Administration) will serve to provide all management and oversight functions for the overall Drogram. It will also function to facilitate communications amongs project leaders. It will serve as support for manuscript/grant/progress report preparation, and for data posting on the web. Core structure is to have a PI, and Executive Advisory, and Interanl Review committee and a Board of External Reviewers. LAY SUMMARY: This core will provide overall organization for the overall program. This is necessary to meet the experimental goals of the projects, each of which has important public health implications.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL055552-15
Application #
8318866
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
2013-08-31
Budget Start
2011-09-01
Budget End
2012-08-31
Support Year
15
Fiscal Year
2011
Total Cost
$86,042
Indirect Cost

  Institution

Name
University of Minnesota Twin Cities
Department
Type
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455

  Publications

Solovey, Anna; Somani, Arif; Belcher, John D et al. (2017) A monocyte-TNF-endothelial activation axis in sickle transgenic mice: Therapeutic benefit from TNF blockade. Am J Hematol 92:1119-1130
Belcher, John D; Chen, Chunsheng; Nguyen, Julia et al. (2014) Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease. Blood 123:377-90
Shirodkar, Apurva V; St Bernard, Rosanne; Gavryushova, Anna et al. (2013) A mechanistic role for DNA methylation in endothelial cell (EC)-enriched gene expression: relationship with DNA replication timing. Blood 121:3531-40
Schaer, Dominik J; Buehler, Paul W; Alayash, Abdu I et al. (2013) Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins. Blood 121:1276-84
Nath, Karl A; Grande, Joseph P; Farrugia, Gianrico et al. (2013) Age sensitizes the kidney to heme protein-induced acute kidney injury. Am J Physiol Renal Physiol 304:F317-25
Mulrooney, Daniel A; Ness, Kirsten K; Huang, Sujuan et al. (2013) Pilot study of vascular health in survivors of osteosarcoma. Pediatr Blood Cancer 60:1703-8
Weber, M L; Chen, C; Li, Y et al. (2013) Morphine stimulates platelet-derived growth factor receptor-? signalling in mesangial cells in vitro and transgenic sickle mouse kidney in vivo. Br J Anaesth 111:1004-12
Martin-Ramirez, Javier; Hofman, Menno; van den Biggelaar, Maartje et al. (2012) Establishment of outgrowth endothelial cells from peripheral blood. Nat Protoc 7:1709-15
Nath, Karl A (2012) Human AKI and heme oxygenase-1. J Am Soc Nephrol 23:971-4
Juskewitch, Justin E; Knudsen, Bruce E; Platt, Jeffrey L et al. (2012) LPS-induced murine systemic inflammation is driven by parenchymal cell activation and exclusively predicted by early MCP-1 plasma levels. Am J Pathol 180:32-40

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