Abstract

The Specific Aims of the Core are: 4) To produce, maintain and monitor swine in various combinations of diabetes and lipemia, and provide tissue, serum, plasma and urine samples as well as blood monocytes and arterial smooth muscle and endothelial cells from these animals as dictated by the needs of scientific projects in this PPG; 5) To provide pathological analysis (including quantitative image analysis), on gross, histological and cellular specimens derived from these animals, and carry out or assist in immunohistochemical studies on specimens as required by the scientific projects. 6) To develop modifications of the diabetic swine model for studies applicable to the human disease (ex., impaired glucose tolerance), together with techniques for delivering pharmacological interventions (ex., osmotic mini-pumps, time-release pellets); 7) To develop, in collaborations with investigators at UVA (Sarembock, French, Nadler), a coronary artery stent model in the diabetic swine model.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL055798-07
Application #
6642926
Study Section
Heart, Lung, and Blood Program Project Review Committee (HLBP)
Project Start
2002-08-01
Project End
2003-07-31
Budget Start
Budget End
Support Year
7
Fiscal Year
2002
Total Cost
Indirect Cost

  Institution

Name
University of Virginia
Department
Type
DUNS #
001910777
City
Charlottesville
State
VA
Country
United States
Zip Code
22904

  Publications

Jeong, Se-Jin; Kim, Sinai; Park, Jong-Gil et al. (2018) Prdx1 (peroxiredoxin 1) deficiency reduces cholesterol efflux via impaired macrophage lipophagic flux. Autophagy 14:120-133
Gao, Chuan; Tabb, Keri L; Dimitrov, Latchezar M et al. (2018) Exome Sequencing Identifies Genetic Variants Associated with Circulating Lipid Levels in Mexican Americans: The Insulin Resistance Atherosclerosis Family Study (IRASFS). Sci Rep 8:5603
Gaddis, Dalia E; Padgett, Lindsey E; Wu, Runpei et al. (2018) Apolipoprotein AI prevents regulatory to follicular helper T cell switching during atherosclerosis. Nat Commun 9:1095
Que, Xuchu; Hung, Ming-Yow; Yeang, Calvin et al. (2018) Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice. Nature 558:301-306
Senders, Max L; Que, Xuchu; Cho, Young Seok et al. (2018) PET/MR Imaging of Malondialdehyde-Acetaldehyde Epitopes With a Human Antibody Detects Clinically Relevant Atherothrombosis. J Am Coll Cardiol 71:321-335
Srikakulapu, Prasad; Upadhye, Aditi; Rosenfeld, Sam M et al. (2017) Perivascular Adipose Tissue Harbors Atheroprotective IgM-Producing B Cells. Front Physiol 8:719
Liu, Chao; Gaudet, Daniel; Miller, Yury I (2017) Deficient Cholesterol Esterification in Plasma of apoc2 Knockout Zebrafish and Familial Chylomicronemia Patients. PLoS One 12:e0169939
Thomas, Graham D; Hamers, Anouk A J; Nakao, Catherine et al. (2017) Human Blood Monocyte Subsets: A New Gating Strategy Defined Using Cell Surface Markers Identified by Mass Cytometry. Arterioscler Thromb Vasc Biol 37:1548-1558
Nowyhed, Heba N; Chandra, Shilpi; Kiosses, William et al. (2017) ATP Binding Cassette Transporter ABCA7 Regulates NKT Cell Development and Function by Controlling CD1d Expression and Lipid Raft Content. Sci Rep 7:40273
Byun, Young Sup; Yang, Xiaohong; Bao, Weihang et al. (2017) Oxidized Phospholipids on Apolipoprotein B-100 and Recurrent Ischemic Events Following Stroke or Transient Ischemic Attack. J Am Coll Cardiol 69:147-158

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