Abstract

Overview: Tissues from genetically manipulated mice are analyzed by this Core facility using various histochemical and immunohistochemical assays. Tissues from normal littermate controls are compared with those obtained from genetically manipulated mice; to identify specific changes in phenotype as evidenced by changes in morphology or changes in binding to a variety of markers (e.g., antibodies or lectins).

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
2P01HL057345-06
Application #
6704468
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
2003-02-01
Project End
2007-11-30
Budget Start
2003-02-01
Budget End
2003-11-30
Support Year
6
Fiscal Year
2003
Total Cost
$131,176
Indirect Cost

  Institution

Name
University of California San Diego
Department
Type
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093

  Publications

Sato, Emi; Zhang, Ling-Juan; Dorschner, Robert A et al. (2017) Activation of Parathyroid Hormone 2 Receptor Induces Decorin Expression and Promotes Wound Repair. J Invest Dermatol 137:1774-1783
Johns, Scott C; Yin, Xin; Jeltsch, Michael et al. (2016) Functional Importance of a Proteoglycan Coreceptor in Pathologic Lymphangiogenesis. Circ Res 119:210-21
Mooij, Hans L; Bernelot Moens, Sophie J; Gordts, Philip L S M et al. (2015) Ext1 heterozygosity causes a modest effect on postprandial lipid clearance in humans. J Lipid Res 56:665-73
Kawamura, Tetsuya; Stephens, Bryan; Qin, Ling et al. (2014) A general method for site specific fluorescent labeling of recombinant chemokines. PLoS One 9:e81454
Muto, Jun; Morioka, Yasuhide; Yamasaki, Kenshi et al. (2014) Hyaluronan digestion controls DC migration from the skin. J Clin Invest 124:1309-19
Mooij, H L; Cabrales, P; Bernelot Moens, S J et al. (2014) Loss of function in heparan sulfate elongation genes EXT1 and EXT 2 results in improved nitric oxide bioavailability and endothelial function. J Am Heart Assoc 3:e001274
Yin, Xin; Johns, Scott C; Kim, Daniel et al. (2014) Lymphatic specific disruption in the fine structure of heparan sulfate inhibits dendritic cell traffic and functional T cell responses in the lymph node. J Immunol 192:2133-42
Chang, Yung-Chi; Olson, Joshua; Beasley, Federico C et al. (2014) Group B Streptococcus engages an inhibitory Siglec through sialic acid mimicry to blunt innate immune and inflammatory responses in vivo. PLoS Pathog 10:e1003846
Schommer, Nina N; Muto, Jun; Nizet, Victor et al. (2014) Hyaluronan breakdown contributes to immune defense against group A Streptococcus. J Biol Chem 289:26914-21
Xu, Ding; Young, Jeffrey H; Krahn, Juno M et al. (2013) Stable RAGE-heparan sulfate complexes are essential for signal transduction. ACS Chem Biol 8:1611-20

Showing the most recent 10 out of 140 publications