Abstract

: The Flow Cytometry Core, under the supervision of Dr. Engleman, will support all three of the projects by providing cell sorting and immunofluorescence analysis services. Equipment available to this core, which is located at the Stanford Blood Center, include a FACS VantageTM flow cytometer capable of four color fluorescence analysis as well as automated cell sorting, A FACSCaliburTM analyzer, and a Baker 9118AX cell counter. Extensive utilization of this core is anticipated, since identification, isolation and phenotype analysis of leukocyte subpopulations are required for the projects being serviced.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
2P01HL057443-06
Application #
6594627
Study Section
Project Start
2002-06-01
Project End
2007-05-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
6
Fiscal Year
2002
Total Cost
$189,283
Indirect Cost

  Institution

Name
Stanford University
Department
Type
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305

  Publications

Söderström, Kalle; Stein, Emily; Colmenero, Paula et al. (2010) Natural killer cells trigger osteoclastogenesis and bone destruction in arthritis. Proc Natl Acad Sci U S A 107:13028-33
Yao, Zhenyu; Liu, Yinping; Jones, Jennifer et al. (2009) Differences in Bcl-2 expression by T-cell subsets alter their balance after in vivo irradiation to favor CD4+Bcl-2hi NKT cells. Eur J Immunol 39:763-75
Franki, Suzanne N; Steward, Kristopher K; Betting, David J et al. (2008) Dendritic cells loaded with apoptotic antibody-coated tumor cells provide protective immunity against B-cell lymphoma in vivo. Blood 111:1504-11
Mende, Ines; Engleman, Edgar G (2007) Breaking self-tolerance to tumor-associated antigens by in vivo manipulation of dendritic cells. Methods Mol Biol 380:457-68
Pillai, A; Teo, P; George, T et al. (2007) Alloantigen recognition is critical for CD8 T cell-mediated graft anti-tumor activity against murine BCL1 lymphoma after myeloablative bone marrow transplantation. Bone Marrow Transplant 40:487-97
Zhang, Angela L; Colmenero, Paula; Purath, Ulrich et al. (2007) Natural killer cells trigger differentiation of monocytes into dendritic cells. Blood 110:2484-93
Colmenero, Paula; Zhang, Angela L; Qian, Ting et al. (2007) Qa-1(b)-dependent modulation of dendritic cell and NK cell cross-talk in vivo. J Immunol 179:4608-15
Pillai, Asha B; George, Tracy I; Dutt, Suparna et al. (2007) Host NKT cells can prevent graft-versus-host disease and permit graft antitumor activity after bone marrow transplantation. J Immunol 178:6242-51
Mende, Ines; Karsunky, Holger; Weissman, Irving L et al. (2006) Flk2+ myeloid progenitors are the main source of Langerhans cells. Blood 107:1383-90
Takahashi, Tsuyoshi; Dejbakhsh-Jones, Sussan; Strober, Samuel (2006) Expression of CD161 (NKR-P1A) defines subsets of human CD4 and CD8 T cells with different functional activities. J Immunol 176:211-6

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