Abstract

Objective: The purpose of the Administrative Core Unit is to provide overall direction and oversight of theProgram, promote interaction among the investigators, and provide effective budget management andadministrative assistance.Description: The offices of Dr. Shattil and Tawana Young are located immediately adjacent to thelaboratories of Dr. Shattil and Ginsberg. The program will require extensive interactions between theparticipants, as well as access to the central UCSD electronic mail system, computing facilities and fiscalmanagement software. The Administrative Core Unit will coordinate the monitoring of research within andbetween projects, optimize utilization of the other core units, interact with departmental and UCSD fundmanagers, schedule 'work-in-progress' research meetings and meetings of the Advisory Boards, andprepare reports to the NIH.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
2P01HL057900-12A1
Application #
7425548
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
2007-12-01
Project End
2012-11-30
Budget Start
2007-12-01
Budget End
2009-01-31
Support Year
12
Fiscal Year
2008
Total Cost
$43,913
Indirect Cost

  Institution

Name
University of California San Diego
Department
Type
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093

  Publications

Wilson, RaeAnna; Espinosa-Diez, Cristina; Kanner, Nathan et al. (2016) MicroRNA regulation of endothelial TREX1 reprograms the tumour microenvironment. Nat Commun 7:13597
Liao, Zhongji; Kato, Hisashi; Pandey, Manjula et al. (2015) Interaction of kindlin-2 with integrin ?3 promotes outside-in signaling responses by the ?V?3 vitronectin receptor. Blood 125:1995-2004
Desgrosellier, Jay S; Lesperance, Jacqueline; Seguin, Laetitia et al. (2014) Integrin ?v?3 drives slug activation and stemness in the pregnant and neoplastic mammary gland. Dev Cell 30:295-308
Fitzpatrick, Paul; Shattil, Sanford J; Ablooglu, Ararat J (2014) C-terminal COOH of integrin ?1 is necessary for ?1 association with the kindlin-2 adapter protein. J Biol Chem 289:11183-93
Seguin, Laetitia; Kato, Shumei; Franovic, Aleksandra et al. (2014) An integrin ??-KRAS-RalB complex drives tumour stemness and resistance to EGFR inhibition. Nat Cell Biol 16:457-68
Casar, B; Rimann, I; Kato, H et al. (2014) In vivo cleaved CDCP1 promotes early tumor dissemination via complexing with activated ?1 integrin and induction of FAK/PI3K/Akt motility signaling. Oncogene 33:255-68
Ye, Feng; Petrich, Brian G; Anekal, Praju et al. (2013) The mechanism of kindlin-mediated activation of integrin ?IIb?3. Curr Biol 23:2288-2295
Ye, Feng; Kim, Chungho; Ginsberg, Mark H (2012) Reconstruction of integrin activation. Blood 119:26-33
Scheppke, Lea; Murphy, Eric A; Zarpellon, Alessandro et al. (2012) Notch promotes vascular maturation by inducing integrin-mediated smooth muscle cell adhesion to the endothelial basement membrane. Blood 119:2149-58
Cantor, Joseph M; Ginsberg, Mark H (2012) CD98 at the crossroads of adaptive immunity and cancer. J Cell Sci 125:1373-82

Showing the most recent 10 out of 79 publications