The Small Animal Core: Models of Acute Lung Injury (ALI) will provide two major core functions to supportthe PPG's research investigators and five research projects. The first function is providing murine models ofALI (LPS- and vertilator-induced) with the core ensuring reproducible studies with a complete range ofexpertise and tools to obtain critical information pertaining to the cellular and molecular basis of endothelialbarrier permeability. The Core, using well published techniques and parameters of acute lung injury, willemploy state-of-the-art evaluation of pulmonary pathophysiology, interventions, data analysis, andinterpretation, in order to provide insight into the efficacy and mechanisms of clinically relevant managementapproaches and to facilitate the translation of basic research to the clinical arena. The Core will takeadvantage of the resources available at the University of Chicago Small Animal Imaging core (which includesMRI, CT Optical Imaging, etc. This Core provides quantitative measurements of permeability, inflammation,edema, vascular leak and biomarkers. A second core function is to care for the wild type and geneticallyengineeredmice utilized in this Program and to generate novel transgenic mice where indicated. Coreleaders have assembled talented and well published personnel and enjoy newly built laboratory facilities tosatisfy a wide range of experimental physiological and imaging needs. Core C personnel have professionalexperience spanning the fields of physiology, microsurgery, biology, and animal care and has alreadyprovided convincing evidence of coherent interactions with investigators of all five research projectsdelivering key preliminary results related to our PPG projects.
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