In the first cycle of this P01, our collective and synergistic efforts have clearly established the validity of our central hypothesis that """"""""excessive TGFB signaling plays a key role in the pathobiology of the neonatal chronic lung injury termed BPD"""""""". The logical extension of these findings """"""""what's upstream and downstream of TGF in chronic neonatal lung injury and are there any useful therapeutic targets in this pathway?"""""""" is a key question that will be the focus of this revised renewal application. Thus, we propose a research program to address the following 5 inter-related, mutually reinforcing and synergistic aspects of this key question. Project 1. Warburton and Gauldie. Excess TGFB in neonatal lung injury and repair. Project 2. Minoo. BPD: interactions between inflammation and morphogenesis. Project 3. Derynck. Non-Smad mechanisms of TGFB signaling Project 4. Groffen. Negative regulation of lung inflammation by Abr/Bcr. Project 5. Bellusci. FGFR2b pathway in Bronchopulmonary Dysplasia.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL060231-08
Application #
7228094
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Program Officer
Blaisdell, Carol J
Project Start
1998-04-01
Project End
2010-03-31
Budget Start
2007-04-01
Budget End
2008-03-31
Support Year
8
Fiscal Year
2007
Total Cost
$1,781,539
Indirect Cost
Name
Children's Hospital of Los Angeles
Department
Type
DUNS #
052277936
City
Los Angeles
State
CA
Country
United States
Zip Code
90027
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