Abstract

The purpose of this Core is to provide a consistent preparation of animal models across the various projects. It will be the responsibility of this Core to prepare the chronic animal models for the individual investigators. This will reduce the variability of preparations and will release the individual project directors from the extremely labor intensive task of creating these preparations and care for their immediate post operative recovery. The various animal models will be prepared by or under the director of Dr. Cornish who has had many years of experience in the preparation of chronic animals and is experienced in these specific animal preparations. We will be assisted by two technicians in the preparation and care of the animals prior to their use by the various investigators. The models prepared by this core will be (1) the coronary ligation model of heart failure (HF) in the rat, () the pacing model of HF in the rabbit, and (3) the pacing model of HF in the dog.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL062222-03
Application #
6457668
Study Section
Project Start
2001-07-01
Project End
2002-06-30
Budget Start
Budget End
Support Year
3
Fiscal Year
2001
Total Cost
$142,461
Indirect Cost

  Institution

Name
University of Nebraska Medical Center
Department
Type
DUNS #
City
Omaha
State
NE
Country
United States
Zip Code
68198

  Publications

Tian, Changhai; Gao, Lie; Zimmerman, Matthew C et al. (2018) Myocardial infarction-induced microRNA-enriched exosomes contribute to cardiac Nrf2 dysregulation in chronic heart failure. Am J Physiol Heart Circ Physiol 314:H928-H939
Marcus, Noah J; Del Rio, Rodrigo; Ding, Yanfeng et al. (2018) KLF2 mediates enhanced chemoreflex sensitivity, disordered breathing and autonomic dysregulation in heart failure. J Physiol 596:3171-3185
Fontes, Marco Antônio Peliky; Vaz, Gisele Cristiane; Cardoso, Thais Zielke Dias et al. (2018) GABA-containing liposomes: neuroscience applications and translational perspectives for targeting neurological diseases. Nanomedicine 14:781-788
de Morais, Sharon D B; Shanks, Julia; Zucker, Irving H (2018) Integrative Physiological Aspects of Brain RAS in Hypertension. Curr Hypertens Rep 20:10
Zheng, Hong; Katsurada, Kenichi; Liu, Xuefei et al. (2018) Specific Afferent Renal Denervation Prevents Reduction in Neuronal Nitric Oxide Synthase Within the Paraventricular Nucleus in Rats With Chronic Heart Failure. Hypertension 72:667-675
Lewis, Robert; Hackfort, Bryan T; Schultz, Harold D (2018) Chronic Heart Failure Abolishes Circadian Rhythms in Resting and Chemoreflex Breathing. Adv Exp Med Biol 1071:129-136
Schiller, Alicia M; Pellegrino, Peter Ricci; Zucker, Irving H (2017) Eppur Si Muove: The dynamic nature of physiological control of renal blood flow by the renal sympathetic nerves. Auton Neurosci 204:17-24
Del Rio, Rodrigo; Andrade, David C; Toledo, Camilo et al. (2017) Carotid Body-Mediated Chemoreflex Drive in The Setting of low and High Output Heart Failure. Sci Rep 7:8035
Becker, Bryan K; Wang, Hanjun; Zucker, Irving H (2017) Central TrkB blockade attenuates ICV angiotensin II-hypertension and sympathetic nerve activity in male Sprague-Dawley rats. Auton Neurosci 205:77-86
Zheng, Hong; Liu, Xuefei; Li, Yulong et al. (2017) A Hypothalamic Leptin-Glutamate Interaction in the Regulation of Sympathetic Nerve Activity. Neural Plast 2017:2361675

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