Abstract

1. Surgical Animal Models for Studying Cardiac Hypertrophy and Failure The Director of the Animal Physiology Core has developed a number of surgical models that induce cardiac hypertrophy and failure in the rodent. In Projects 1,2 and 3 (Solaro, Russell, Lewandowski), transverse thoracic aortic banding will be used to examine the effect of superimposing a systolic pressure overload on mice that overexpress transgenes of sarcomeric and intracellular signaling proteins in the heart. Project 2 also includes a model of arteriovenous insufficiency in mice to induce a volume overload on the left ventricle. Guinea pigs (DeTombe, Project 4) will be subjected to pressure and volume overload induced by transverse thoracic aortic coarctation or aortic insufficiency (aortic valve leaflet damage). These studies will examine the effect of ventricular remodeling and failure on isolated muscle function and the role that phosphorylation of sarcomeric proteins play in cardiac dysfunction.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL062426-14
Application #
8467014
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
Budget Start
2013-03-01
Budget End
2014-02-28
Support Year
14
Fiscal Year
2013
Total Cost
$452,644
Indirect Cost
$106,355

  Institution

Name
University of Illinois at Chicago
Department
Type
DUNS #
098987217
City
Chicago
State
IL
Country
United States
Zip Code
60612

  Publications

Le, Long V; Mohindra, Priya; Fang, Qizhi et al. (2018) Injectable hyaluronic acid based microrods provide local micromechanical and biochemical cues to attenuate cardiac fibrosis after myocardial infarction. Biomaterials 169:11-21
Mkrtschjan, Michael A; Gaikwad, Snehal B; Kappenman, Kevin J et al. (2018) Lipid signaling affects primary fibroblast collective migration and anchorage in response to stiffness and microtopography. J Cell Physiol 233:3672-3683
Yan, Jiajie; Thomson, Justin K; Zhao, Weiwei et al. (2018) Role of Stress Kinase JNK in Binge Alcohol-Evoked Atrial Arrhythmia. J Am Coll Cardiol 71:1459-1470
Bohlooli Ghashghaee, Nazanin; Li, King-Lun; Solaro, R John et al. (2018) Role of the C-terminus mobile domain of cardiac troponin I in the regulation of thin filament activation in skinned papillary muscle strips. Arch Biochem Biophys 648:27-35
Yan, Jiajie; Zhao, Weiwei; Thomson, Justin K et al. (2018) Stress Signaling JNK2 Crosstalk With CaMKII Underlies Enhanced Atrial Arrhythmogenesis. Circ Res 122:821-835
Ait Mou, Younss; Lacampagne, Alain; Irving, Thomas et al. (2018) Altered myofilament structure and function in dogs with Duchenne muscular dystrophy cardiomyopathy. J Mol Cell Cardiol 114:345-353
Dvornikov, Alexey V; de Tombe, Pieter P; Xu, Xiaolei (2018) Phenotyping cardiomyopathy in adult zebrafish. Prog Biophys Mol Biol 138:116-125
Ferrantini, Cecilia; Coppini, Raffaele; Pioner, Josè Manuel et al. (2017) Pathogenesis of Hypertrophic Cardiomyopathy is Mutation Rather Than Disease Specific: A Comparison of the Cardiac Troponin T E163R and R92Q Mouse Models. J Am Heart Assoc 6:
Alves, Marco L; Warren, Chad M; Simon, Jillian N et al. (2017) Early sensitization of myofilaments to Ca2+ prevents genetically linked dilated cardiomyopathy in mice. Cardiovasc Res 113:915-925
Zak, Taylor J; Koshman, Yevgenia E; Samarel, Allen M et al. (2017) Regulation of Focal Adhesion Kinase through a Direct Interaction with an Endogenous Inhibitor. Biochemistry 56:4722-4731

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