Abstract

The application of transgenic and chimeric and approaches represent a major activity of this program. The Transgenic Core provides the scientific staff, mouse breeding colonies, and specialized equipment needed to generate transgenic mice as well as produce chimeric mice for the program's investigators. The services offered include generation of transgenic mice, production of embryonic stem cell chimeras, ovary transplantation, freezing of 8-cell embryos for preservation of mouse strains, embryo transfer to reconstitute mice contaminated with pathogens, maintenance of mouse lines, collection of embryos, and testing of ES cell lines for germ line transmission.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL066105-05
Application #
7006139
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
2004-12-01
Project End
2005-11-30
Budget Start
2004-12-01
Budget End
2005-11-30
Support Year
5
Fiscal Year
2005
Total Cost
$432,149
Indirect Cost

  Institution

Name
Massachusetts Institute of Technology
Department
Type
DUNS #
001425594
City
Cambridge
State
MA
Country
United States
Zip Code
02139

  Publications

Murphy, Patrick A; Butty, Vincent L; Boutz, Paul L et al. (2018) Alternative RNA splicing in the endothelium mediated in part by Rbfox2 regulates the arterial response to low flow. Elife 7:
Alvarez-Dominguez, Juan R; Knoll, Marko; Gromatzky, Austin A et al. (2017) The Super-Enhancer-Derived alncRNA-EC7/Bloodlinc Potentiates Red Blood Cell Development in trans. Cell Rep 19:2503-2514
Alvarez-Dominguez, Juan R; Lodish, Harvey F (2017) Emerging mechanisms of long noncoding RNA function during normal and malignant hematopoiesis. Blood 130:1965-1975
Dockendorff, Chris; Faloon, Patrick W; Germain, Andrew et al. (2015) Discovery of bisamide-heterocycles as inhibitors of scavenger receptor BI (SR-BI)-mediated lipid uptake. Bioorg Med Chem Lett 25:2594-8
Turner, Christopher J; Badu-Nkansah, Kwabena; Crowley, Denise et al. (2015) ?5 and ?v integrins cooperate to regulate vascular smooth muscle and neural crest functions in vivo. Development 142:797-808
Alvarez-Dominguez, Juan R; Bai, Zhiqiang; Xu, Dan et al. (2015) De Novo Reconstruction of Adipose Tissue Transcriptomes Reveals Long Non-coding RNA Regulators of Brown Adipocyte Development. Cell Metab 21:764-776
Dockendorff, Chris; Faloon, Patrick W; Pu, Jun et al. (2015) Benzo-fused lactams from a diversity-oriented synthesis (DOS) library as inhibitors of scavenger receptor BI (SR-BI)-mediated lipid uptake. Bioorg Med Chem Lett 25:2100-5
Murphy, Patrick A; Begum, Shahinoor; Hynes, Richard O (2015) Tumor angiogenesis in the absence of fibronectin or its cognate integrin receptors. PLoS One 10:e0120872
Hu, Wenqian; Yuan, Bingbing; Lodish, Harvey F (2014) Cpeb4-mediated translational regulatory circuitry controls terminal erythroid differentiation. Dev Cell 30:660-72
Alvarez-Dominguez, Juan R; Hu, Wenqian; Gromatzky, Austin A et al. (2014) Long noncoding RNAs during normal and malignant hematopoiesis. Int J Hematol 99:531-41

Showing the most recent 10 out of 118 publications