Abstract

The mouse husbandry and genotyping core will support the use of mice in this program by: 1) performing routine husbandry of transgenic, knockout, and other mice for all proposed, 2) determining genotypes of transgenic and knockout mice, 3) cross-breeding genetically defined mouse strains, 2) distributing and knockout mice to investigators in the individual projects. This core will work with the Vanderbilt University Animal Care Facility the use of genetically defined mice for use in the study of inflammation.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL066196-02
Application #
6842695
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
Budget Start
2002-12-01
Budget End
2003-11-30
Support Year
2
Fiscal Year
2003
Total Cost
$278,671
Indirect Cost

  Institution

Name
Vanderbilt University Medical Center
Department
Type
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212

  Publications

Tiriveedhi, Venkataswarup; Upadhya, Gundumi A; Busch, Rebecca A et al. (2014) Protective role of bortezomib in steatotic liver ischemia/reperfusion injury through abrogation of MMP activation and YKL-40 expression. Transpl Immunol 30:93-8
Ramachandran, Sabarinathan; Liaw, Jane M; Jia, Jianluo et al. (2012) Ischemia-reperfusion injury in rat steatotic liver is dependent on NF?B P65 activation. Transpl Immunol 26:201-6
Tiriveedhi, Venkataswarup; Conzen, Kendra D; Liaw-Conlin, Jane et al. (2012) The role of molecular chaperonins in warm ischemia and reperfusion injury in the steatotic liver: a proteomic study. BMC Biochem 13:17
Lee, Hye Jeong; Joo, Myungsoo; Abdolrasulnia, Rasul et al. (2010) Peptidylarginine deiminase 2 suppresses inhibitory {kappa}B kinase activity in lipopolysaccharide-stimulated RAW 264.7 macrophages. J Biol Chem 285:39655-62
Joo, Myungsoo; Kwon, Minjae; Cho, Yong-Jig et al. (2009) Lipopolysaccharide-dependent interaction between PU.1 and c-Jun determines production of lipocalin-type prostaglandin D synthase and prostaglandin D2 in macrophages. Am J Physiol Lung Cell Mol Physiol 296:L771-9
Han, Wei; Joo, Myungsoo; Everhart, M Brett et al. (2009) Myeloid cells control termination of lung inflammation through the NF-kappaB pathway. Am J Physiol Lung Cell Mol Physiol 296:L320-7
Joo, Myungsoo; Kwon, Minjae; Azim, Anser C et al. (2008) Genetic determination of the role of PU.1 in macrophage gene expression. Biochem Biophys Res Commun 372:97-102
Chen, S M; Cheng, D-S; Williams, B J et al. (2008) The nuclear factor kappa-B pathway in airway epithelium regulates neutrophil recruitment and host defence following Pseudomonas aeruginosa infection. Clin Exp Immunol 153:420-8
Cao, Hongmei; Xiao, Lei; Park, Gyeyoung et al. (2008) An improved LC-MS/MS method for the quantification of prostaglandins E(2) and D(2) production in biological fluids. Anal Biochem 372:41-51
Stathopoulos, Georgios T; Sherrill, Taylor P; Han, Wei et al. (2008) Host nuclear factor-kappaB activation potentiates lung cancer metastasis. Mol Cancer Res 6:364-71

Showing the most recent 10 out of 46 publications