Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL066254-02
Application #
6642931
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
2002-08-01
Project End
2003-07-31
Budget Start
2002-08-01
Budget End
2003-07-31
Support Year
2
Fiscal Year
2002
Total Cost
$213,409
Indirect Cost
Name
University of Colorado Denver
Department
Type
DUNS #
065391526
City
Aurora
State
CO
Country
United States
Zip Code
80045
Sakao, Seiichiro; Tatsumi, Koichiro; Voelkel, Norbert F (2010) Reversible or irreversible remodeling in pulmonary arterial hypertension. Am J Respir Cell Mol Biol 43:629-34
Sakao, Seiichiro; Tatsumi, Koichiro; Voelkel, Norbert F (2009) Endothelial cells and pulmonary arterial hypertension: apoptosis, proliferation, interaction and transdifferentiation. Respir Res 10:95
Rai, Pradeep R; Cool, Carlyne D; King, Judy A C et al. (2008) The cancer paradigm of severe pulmonary arterial hypertension. Am J Respir Crit Care Med 178:558-64
Taraseviciene-Stewart, Laimute; Nicolls, Mark R; Kraskauskas, Donatas et al. (2007) Absence of T cells confers increased pulmonary arterial hypertension and vascular remodeling. Am J Respir Crit Care Med 175:1280-9
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Sakao, Seiichiro; Taraseviciene-Stewart, Laimute; Cool, Carlyne D et al. (2007) VEGF-R blockade causes endothelial cell apoptosis, expansion of surviving CD34+ precursor cells and transdifferentiation to smooth muscle-like and neuronal-like cells. FASEB J 21:3640-52
Oka, Masahiko; Homma, Noriyuki; Taraseviciene-Stewart, Laimute et al. (2007) Rho kinase-mediated vasoconstriction is important in severe occlusive pulmonary arterial hypertension in rats. Circ Res 100:923-9
Sakao, Seiichiro; Taraseviciene-Stewart, Laimute; Wood, Kathy et al. (2006) Apoptosis of pulmonary microvascular endothelial cells stimulates vascular smooth muscle cell growth. Am J Physiol Lung Cell Mol Physiol 291:L362-8
Taraseviciene-Stewart, Laimute; Scerbavicius, Robertas; Choe, Kang-Hyeon et al. (2006) Simvastatin causes endothelial cell apoptosis and attenuates severe pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol 291:L668-76
Taraseviciute, Agne; Voelkel, Norbert F (2006) Severe pulmonary hypertension in postmenopausal obese women. Eur J Med Res 11:198-202

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