Abstract

This Core has two major goals or aims that are essential for the success of all four Projects and the Program itself. These two major goals are to obtain and maintain established mouse lines that are needed for the progress of Programmatic use, to provide a facility for the generation, propagation and distribution of viral vectors for analysis of coronary vessel development. The Core will also provide Core B, the Morphology and Imaging Core, materials for immunochemical analysis in the generation of our """"""""Index of Gene Expression in the Developing Coronary System."""""""" There are two components of the Core housed at Vanderbilt and Cornell Universities. This arrangement takes advantage of the expertise, facilities and equipment already in place and negates major changes in personal, training and logistics. This Core is essential for the maintaining the integrated nature of all four Projects of the Program and provides the most efficient and cost effective use of resources.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL067105-04
Application #
6893313
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
2004-05-01
Project End
2006-04-30
Budget Start
2004-05-01
Budget End
2005-04-30
Support Year
4
Fiscal Year
2004
Total Cost
$115,118
Indirect Cost

  Institution

Name
Vanderbilt University Medical Center
Department
Type
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212

  Publications

Criswell, Tracy L; Dumont, Nancy; Barnett, Joey V et al. (2008) Knockdown of the transforming growth factor-beta type III receptor impairs motility and invasion of metastatic cancer cells. Cancer Res 68:7304-12
Hayashi, Hisaki; Kume, Tsutomu (2008) Foxc transcription factors directly regulate Dll4 and Hey2 expression by interacting with the VEGF-Notch signaling pathways in endothelial cells. PLoS One 3:e2401
Hayashi, Hisaki; Sano, Hideto; Seo, Seungwoon et al. (2008) The Foxc2 transcription factor regulates angiogenesis via induction of integrin beta3 expression. J Biol Chem 283:23791-800
Hayashi, Hisaki; Kume, Tsutomu (2008) Forkhead transcription factors regulate expression of the chemokine receptor CXCR4 in endothelial cells and CXCL12-induced cell migration. Biochem Biophys Res Commun 367:584-9
Austin, Anita F; Compton, Leigh A; Love, Joseph D et al. (2008) Primary and immortalized mouse epicardial cells undergo differentiation in response to TGFbeta. Dev Dyn 237:366-76
Compton, Leigh A; Potash, Dru A; Brown, Christopher B et al. (2007) Coronary vessel development is dependent on the type III transforming growth factor beta receptor. Circ Res 101:784-91
Fujita, Hideo; Kang, Myengmo; Eren, Mesut et al. (2006) Foxc2 is a common mediator of insulin and transforming growth factor beta signaling to regulate plasminogen activator inhibitor type I gene expression. Circ Res 98:626-34
Smith, Travis K; Bader, David M (2006) Characterization of Bves expression during mouse development using newly generated immunoreagents. Dev Dyn 235:1701-8
Compton, Leigh A; Potash, Dru A; Mundell, Nathan A et al. (2006) Transforming growth factor-beta induces loss of epithelial character and smooth muscle cell differentiation in epicardial cells. Dev Dyn 235:82-93
Seo, Seungwoon; Fujita, Hideo; Nakano, Atsushi et al. (2006) The forkhead transcription factors, Foxc1 and Foxc2, are required for arterial specification and lymphatic sprouting during vascular development. Dev Biol 294:458-70

Showing the most recent 10 out of 23 publications