Abstract

The primary purposes of the Imaging and Cell Biology Core are to provide central facilities and technical assistance for: 1.) imaging of live and fixed cells and tissues, and 2.) isolation of fresh nerve and vascular cells for physiological study (patch clamp, calcium imaging, ROS measurements, contraction assays) and 3.) culture and manipulation of nerve and other cells. By centralizing these core techniques, Core D will enable cost efficiency because a portion of technical help and laboratory facilities/equipment will be provided, avoiding a duplication of efforts and expenditure of money by the investigators. In addition, by providing technical help, Core D provides primary investigators with a degree of quality-control and consistency in experiments as well as additional time in which investigators can follow scientific pursuits.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL070687-10
Application #
8452158
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
2015-01-31
Budget Start
2013-02-01
Budget End
2014-01-31
Support Year
10
Fiscal Year
2013
Total Cost
$147,852
Indirect Cost
$50,554

  Institution

Name
Michigan State University
Department
Type
DUNS #
193247145
City
East Lansing
State
MI
Country
United States
Zip Code
48824

  Publications

Diaz-Otero, Janice Marie; Yen, Ting-Chieh; Fisher, Courtney et al. (2018) Mineralocorticoid Receptor Antagonism Improves Parenchymal Arteriole Dilation Via a TRPV4-Dependent Mechanism and Prevents Cognitive Dysfunction in Hypertension. Am J Physiol Heart Circ Physiol :
Jackson, William F; Boerman, Erika M (2018) Voltage-gated Ca2+ channel activity modulates smooth muscle cell calcium waves in hamster cremaster arterioles. Am J Physiol Heart Circ Physiol 315:H871-H878
Ahmad, Maleeha F; Ferland, David; Ayala-Lopez, Nadia et al. (2018) Perivascular Adipocytes Store Norepinephrine by Vesicular Transport. Arterioscler Thromb Vasc Biol :ATVBAHA118311720
Matin, Nusrat; Fisher, Courtney; Jackson, William F et al. (2018) Carotid artery stenosis in hypertensive rats impairs dilatory pathways in parenchymal arterioles. Am J Physiol Heart Circ Physiol 314:H122-H130
Kumar, Ramya K; Darios, Emma S; Burnett, Robert et al. (2018) Fenfluramine-induced PVAT-dependent contraction depends on norepinephrine and not serotonin. Pharmacol Res :
Thelen, Kyan; Watts, Stephanie W; Contreras, G Andres (2018) Adipogenic potential of perivascular adipose tissue preadipocytes is improved by coculture with primary adipocytes. Cytotechnology 70:1435-1445
Restini, Carolina Baraldi A; Ismail, Alex; Kumar, Ramya K et al. (2018) Renal perivascular adipose tissue: Form and function. Vascul Pharmacol 106:37-45
Jackson, William F (2018) KV channels and the regulation of vascular smooth muscle tone. Microcirculation 25:
Fernandes, Roxanne; Garver, Hannah; Harkema, Jack R et al. (2018) Sex Differences in Renal Inflammation and Injury in High-Fat Diet-Fed Dahl Salt-Sensitive Rats. Hypertension 72:e43-e52
Ayala-Lopez, Nadia; Watts, Stephanie W (2017) New actions of an old friend: perivascular adipose tissue's adrenergic mechanisms. Br J Pharmacol 174:3454-3465

Showing the most recent 10 out of 106 publications