Abstract

The Vector Core will provide viral vectors to investigators for each research project in the context of this Program Project Grant. The Vector Core will construct, produce and test adenovirus-based vectors. These vectors will be used to express CXCR3 ligands, IL-17, IL-17R-IgG, mycobacterial and Pneumocystis antigens, and ovalbumin (OVA) in the lungs of experimental animals outlined in Projects 1, 2 and 4. The Vector Core will also construct, produce and test recombinant fowlpox viruses (FPV) expressing mycobacterial antigens, CXCR3 ligands and OVA. Recombinant FPV vectors will be used in prime-boost approaches outlined in Projects 1 to 4.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
1P01HL076100-01
Application #
6781611
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
2003-12-01
Project End
2008-11-30
Budget Start
2003-12-01
Budget End
2005-01-31
Support Year
1
Fiscal Year
2004
Total Cost
$189,543
Indirect Cost

  Institution

Name
Louisiana State University Hsc New Orleans
Department
Type
DUNS #
782627814
City
New Orleans
State
LA
Country
United States
Zip Code
70112

  Publications

Samuelson, Derrick R; Burnham, Ellen L; Maffei, Vincent J et al. (2018) The respiratory tract microbial biogeography in alcohol use disorder. Am J Physiol Lung Cell Mol Physiol 314:L107-L117
Maffei, Vincent J; Kim, Sangkyu; Blanchard 4th, Eugene et al. (2017) Biological Aging and the Human Gut Microbiota. J Gerontol A Biol Sci Med Sci 72:1474-1482
Byerley, Lauri O; Samuelson, Derrick; Blanchard 4th, Eugene et al. (2017) Changes in the gut microbial communities following addition of walnuts to the diet. J Nutr Biochem 48:94-102
Samuelson, Derrick R; Shellito, Judd E; Maffei, Vincent J et al. (2017) Alcohol-associated intestinal dysbiosis impairs pulmonary host defense against Klebsiella pneumoniae. PLoS Pathog 13:e1006426
Goldsmith, Felicia; Guice, Justin; Page, Ryan et al. (2017) Obese ZDF rats fermented resistant starch with effects on gut microbiota but no reduction in abdominal fat. Mol Nutr Food Res 61:
Ruan, Sanbao; Cai, Yang; Ramsay, Alistair J et al. (2017) B cell and antibody responses in mice induced by a putative cell surface peptidase of Pneumocystis murina protect against experimental infection. Vaccine 35:672-679
Naftolin, Frederick; Mehr, Holly; Fadiel, Ahmed (2016) Sex Steroids Block the Initiation of Atherosclerosis. Reprod Sci 23:1620-1625
Jolley, Sarah E; Alkhafaf, Qasim; Hough, Catherine et al. (2016) Presence of an Alcohol Use Disorder is Associated with Greater Pneumonia Severity in Hospitalized HIV-Infected Patients. Lung 194:755-62
Ruan, S; Samuelson, D R; Assouline, B et al. (2016) Treatment with Interleukin-7 Restores Host Defense against Pneumocystis in CD4+ T-Lymphocyte-Depleted Mice. Infect Immun 84:108-19
Lammi, Matthew R; Ghonim, Mohamed A; Pyakurel, Kusma et al. (2016) Treatment with intranasal iloprost reduces disease manifestations in a murine model of previously established COPD. Am J Physiol Lung Cell Mol Physiol 310:L630-8

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