Abstract

The purpose of this Core is to provide a central location for the supply of mice and services related to mouse care, maintenance, genotyping, and measurement. Specifically this Core will offer the following services: 1. Managing the mouse colony that includes the oversight of the generation, maintenance, and supply of single and compound genetically altered mice. 2. Perform bone marrow transplantation. 3. Measure arterial blood pressure in a standardized manner. 4. Prepare and implant Alzet pumps for the infusion of Angll or saline. 5. Harvest DNA by tail clipping for the purpose of genotyping. 6. In vivo ultrasound. Non-invasively quantify lumen diameter during the evolution of AAAs. Centralization of these facilities will permit an efficient use of resources for the Program, coupled with optimal quality control and standardization across Projects.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL080100-05
Application #
8050626
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
Budget Start
2010-04-01
Budget End
2011-03-31
Support Year
5
Fiscal Year
2010
Total Cost
$211,893
Indirect Cost

  Institution

Name
University of Kentucky
Department
Type
DUNS #
939017877
City
Lexington
State
KY
Country
United States
Zip Code
40506

  Publications

Davis, Frank M; Rateri, Debra L; Daugherty, Alan (2015) Abdominal aortic aneurysm: novel mechanisms and therapies. Curr Opin Cardiol 30:566-73
Liu, Jing; Lu, Hong; Howatt, Deborah A et al. (2015) Associations of ApoAI and ApoB-containing lipoproteins with AngII-induced abdominal aortic aneurysms in mice. Arterioscler Thromb Vasc Biol 35:1826-34
Webb, Nancy R; De Beer, Maria C; Wroblewski, Joanne M et al. (2015) Deficiency of Endogenous Acute-Phase Serum Amyloid A Protects apoE-/- Mice From Angiotensin II-Induced Abdominal Aortic Aneurysm Formation. Arterioscler Thromb Vasc Biol 35:1156-65
Blomkalns, Andra L; Gavrila, Daniel; Thomas, Manesh et al. (2013) CD14 directs adventitial macrophage precursor recruitment: role in early abdominal aortic aneurysm formation. J Am Heart Assoc 2:e000065
Subramanian, Venkateswaran; Moorleghen, Jessica J; Balakrishnan, Anju et al. (2013) Calpain-2 compensation promotes angiotensin II-induced ascending and abdominal aortic aneurysms in calpain-1 deficient mice. PLoS One 8:e72214
Lu, Hong; Rateri, Debra L; Bruemmer, Dennis et al. (2012) Involvement of the renin-angiotensin system in abdominal and thoracic aortic aneurysms. Clin Sci (Lond) 123:531-43
Wang, Shaoping; Subramanian, Venkateswaran; Lu, Hong et al. (2012) Deficiency of receptor-associated protein attenuates angiotensin II-induced atherosclerosis in hypercholesterolemic mice without influencing abdominal aortic aneurysms. Atherosclerosis 220:375-80
Xie, Xiaojie; Lu, Hong; Moorleghen, Jessica J et al. (2012) Doxycycline does not influence established abdominal aortic aneurysms in angiotensin II-infused mice. PLoS One 7:e46411
Rateri, Debra L; Moorleghen, Jessica J; Knight, Victoria et al. (2012) Depletion of endothelial or smooth muscle cell-specific angiotensin II type 1a receptors does not influence aortic aneurysms or atherosclerosis in LDL receptor deficient mice. PLoS One 7:e51483
Subramanian, Venkateswaran; Golledge, Jonathan; Heywood, Elizabeth B et al. (2012) Regulation of peroxisome proliferator-activated receptor-? by angiotensin II via transforming growth factor-?1-activated p38 mitogen-activated protein kinase in aortic smooth muscle cells. Arterioscler Thromb Vasc Biol 32:397-405

Showing the most recent 10 out of 43 publications