IntroductionThe reviewers felt that 'the core is well designed and essential to the proper functioning ofthe Program Project'. No responses are therefore necessary for this Core. Changes areindicated by vertical line in left margin.Rationale and ProceduresThe administrative structure of this Program Project Grant, the responsibilities and the dutiesof the Program Director, have been outlined under 'Organization and AdministrativeStructure' of the Program Overview. Briefly, these include:1. Scientific Responsibilitiesa. Scientific integration, coordination and direction of research projects as needed.b. Encouraging and supporting exploration of new avenues of research and phasingout unpromising research.c. Recruitment of new investigators with promising expertise and direction.d. Consultation with internal advisors and consultants concerning importance andprogress of the research.e. Preparation of scientific progress reports and renewal applications.f. Planning scientific work-in-progress sessions, special seminars and symposia.g. Coordinate and fund use of the Statistical Consulting Center.The Director is aided in these functions primarily by the Co-Director and the members of theInternal Advisory and Executive Committees, and the Extramural Advisory Board.2. Administrative Responsibilitiesa. Following NIH guidelines for Program Project Grant support.b. Allocation of budgets in accordance with NIH policies, recommendations andscientific productivity of projects.Careful justification of expenditures, explorations of more economical or efficientways of using resources, equipment, or supplies.d. Aiding investigators in projecting expenditures and reporting monthly onexpenditures and balance.e. Allocation of travel funds among investigators and research associates in anequitable and fair manner. Allocation of travel for Drs. Davisson and Sharma toperiodically return to Iowa City. Allocation of travel for Pis, postdoctoral fellows andgraduate students to visit Cornell University.f. Preparing annual budgets and projections.g. Circulation of announcements of important events related to the PPG Program.h. Keeping departmental chairs whose members participate in the PPG informed ofdevelopments, effort, contributions, and salary support.i. Informing the Dean of progress, scientific direction, administrative problems andfuture plans.j. Holding regular meetings of the Executive Committee.k. Arrange monthly conference calls between Pis and co-investigators in Iowa withDrs. Davisson and Sharma at Cornell University.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL084207-02
Application #
7700581
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
Budget Start
2008-06-01
Budget End
2009-05-31
Support Year
2
Fiscal Year
2008
Total Cost
$188,655
Indirect Cost
Name
University of Iowa
Department
Type
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Yoon, Young-Sil; Tsai, Wen-Wei; Van de Velde, Sam et al. (2018) cAMP-inducible coactivator CRTC3 attenuates brown adipose tissue thermogenesis. Proc Natl Acad Sci U S A 115:E5289-E5297
Imai, Yumi; Fink, Brian D; Promes, Joseph A et al. (2018) Effect of a mitochondrial-targeted coenzyme Q analog on pancreatic ?-cell function and energetics in high fat fed obese mice. Pharmacol Res Perspect 6:e00393
Morselli, Lisa L; Claflin, Kristin E; Cui, Huxing et al. (2018) Control of Energy Expenditure by AgRP Neurons of the Arcuate Nucleus: Neurocircuitry, Signaling Pathways, and Angiotensin. Curr Hypertens Rep 20:25
Nair, Anand R; Agbor, Larry N; Mukohda, Masashi et al. (2018) Interference With Endothelial PPAR (Peroxisome Proliferator-Activated Receptor)-? Causes Accelerated Cerebral Vascular Dysfunction in Response to Endogenous Renin-Angiotensin System Activation. Hypertension 72:1227-1235
Seoane-Collazo, Patricia; Roa, Juan; Rial-Pensado, Eva et al. (2018) SF1-Specific AMPK?1 Deletion Protects Against Diet-Induced Obesity. Diabetes 67:2213-2226
Schmidt, Eric A; Despas, Fabien; Pavy-Le Traon, Anne et al. (2018) Intracranial Pressure Is a Determinant of Sympathetic Activity. Front Physiol 9:11
Scroggins, Sabrina M; Santillan, Donna A; Lund, Jenna M et al. (2018) Elevated vasopressin in pregnant mice induces T-helper subset alterations consistent with human preeclampsia. Clin Sci (Lond) 132:419-436
Forrester, Steven J; Booz, George W; Sigmund, Curt D et al. (2018) Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology. Physiol Rev 98:1627-1738
Sandgren, Jeremy A; Linggonegoro, Danny W; Zhang, Shao Yang et al. (2018) Angiotensin AT1A receptors expressed in vasopressin-producing cells of the supraoptic nucleus contribute to osmotic control of vasopressin. Am J Physiol Regul Integr Comp Physiol 314:R770-R780
Pellegrinelli, Vanessa; Peirce, Vivian J; Howard, Laura et al. (2018) Adipocyte-secreted BMP8b mediates adrenergic-induced remodeling of the neuro-vascular network in adipose tissue. Nat Commun 9:4974

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