The purpose of Core B - Analytic and Synthetic Chemistry is to carry out two critical functions for each of theprojects. These functions require special scienitific expertise and expensive equipment so establishing acore provides an effective and efficient mechanism to accomplish essential features of the proposal. Theanalytic component of the core will serve all 4 projects and will use mass spectroscopy to identify andcharacterize oxidized phospholipid species derived from PC and PS. The core is well equipped with state-of-the-art mass spectroscopy equipment. The synthetic chemistry component of the core will synthesize welldefined, unique oxidized phospholipid species to be used by all projects to precisely define the role ofspecific receptors, transporters, ligands and enzymes in mediating cellular responses to oxidized lipids. Weare combining two functions (analytic and synthetic) into a single core because the two activities are quiteinterdependent. The synthetic lipids generated will be analyzed and their structures verified by the analyticcomponent with mass spectroscopy and the oxidized phospholipid species identified in the analyticcomponent will then be synthesized by the synthesis component.
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