The purpose of Core A, Administration is to (1) provide administrative and biostatistics support for the Program Director and all of the project and core investigators, and to (2) promote tight coordination, organization and integration of the four Projects and the two scientific cores to maximize productivity and leverage the interdisciplinary synergies of the program. The Administrative Core will be responsible for: 1) All fiscal matters, including: Preparation of monthly statements and annual budgets for the Program Director and each Project and Core Leader;Coordination of all purchase orders for equipment and service contracts;Tracking the proportionate effort of all individuals in projects and cores to assure compliance with the budget. 2.) Arrangement and scheduling of monthly meetings of the Steering Committee to discuss the program's progress, both with respect to scientific as well as operational issues. The steering committee will consist of the Pi's of each project and co-Pi's of each core along. 3.) Scheduling of bi-weekly research in progress seminar series. 4.) Quality control oversight of all communications derived from Program Project activities, including manuscripts, abstracts, oral or poster presentations at scientific and medical symposia, and press releases to translate the findings for the lay community. 5.) Compliance with all institutional and federal processes, including the tracking and oversight of all Human Subject and Animal Research Protocol submissions, and compliance with OSHA, Radiation Safety, and HIPAA regulations. 6.) Communication to all program Pi's and Co-Pi's via e-mail, phone and meetings all information pertinent to the program such as electronic pdf files of newly published manuscripts or summaries of presentations at regional or national meeting that relate to the program. 7.) Provide clerical support for all matters related to the program. 8.) Provide biostatistics support for planning and interpreting mouse and human studies;9.) Arrange the Internal and External Advisory Board meetings to review the program. 10.) Arrange the invitation and visits for outside speakers for the program.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL087018-03
Application #
7841708
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
Budget Start
2009-05-01
Budget End
2010-04-30
Support Year
3
Fiscal Year
2009
Total Cost
$135,903
Indirect Cost
Name
Cleveland Clinic Lerner
Department
Type
DUNS #
135781701
City
Cleveland
State
OH
Country
United States
Zip Code
44195
Silverstein, Roy L (2018) Oxidized Lipid Uptake by Scavenger Receptor CD36 (Cluster of Differentiation 36) Modulates Endothelial Surface Properties and May Contribute to Atherogenesis. Arterioscler Thromb Vasc Biol 38:4-5
Chen, Yiliang; Huang, Wenxin; Yang, Moua et al. (2017) Cardiotonic Steroids Stimulate Macrophage Inflammatory Responses Through a Pathway Involving CD36, TLR4, and Na/K-ATPase. Arterioscler Thromb Vasc Biol 37:1462-1469
Silverstein, Roy L (2017) Linking Metabolic Dysfunction to Atherosclerosis Via Activation of Macrophage CD36 Gene Transcription by Retinol Binding Protein-4. Circulation 135:1355-1356
Ramakrishnan, Devi Prasadh; Hajj-Ali, Rula A; Chen, Yiliang et al. (2016) Extracellular Vesicles Activate a CD36-Dependent Signaling Pathway to Inhibit Microvascular Endothelial Cell Migration and Tube Formation. Arterioscler Thromb Vasc Biol 36:534-44
Gupta, Nilaksh; Li, Wei; McIntyre, Thomas M (2015) Deubiquitinases Modulate Platelet Proteome Ubiquitination, Aggregation, and Thrombosis. Arterioscler Thromb Vasc Biol 35:2657-66
Chadwick, Alexandra C; Holme, Rebecca L; Chen, Yiliang et al. (2015) Acrolein impairs the cholesterol transport functions of high density lipoproteins. PLoS One 10:e0123138
Chen, Yiliang; Kennedy, David J; Ramakrishnan, Devi Prasadh et al. (2015) Oxidized LDL-bound CD36 recruits an Na?/K?-ATPase-Lyn complex in macrophages that promotes atherosclerosis. Sci Signal 8:ra91
Cathcart, Martha K; Bhattacharjee, Ashish (2014) Monoamine oxidase A (MAO-A): a signature marker of alternatively activated monocytes/macrophages. Inflamm Cell Signal 1:
Latchoumycandane, Calivarathan; Nagy, Laura E; McIntyre, Thomas M (2014) Chronic ethanol ingestion induces oxidative kidney injury through taurine-inhibitable inflammation. Free Radic Biol Med 69:403-16
Gupta, Nilaksh; Li, Wei; Willard, Belinda et al. (2014) Proteasome proteolysis supports stimulated platelet function and thrombosis. Arterioscler Thromb Vasc Biol 34:160-8

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