ITashseeLsesmsioentAonfainlysuislin/ Breiosistatatinstcices, aCnodrespweilcliwficorpkawthiwthaeyasc/mholfetchuelethsrienevoplvroejdecintsintosufalincilrietastiestahnecdei,roenct atherosclerotic lesion development and progression. Specifically, the Core will provide quantitative and IqSuearvliticaetivsewaillsisnecslusdmeAn)t oqfuatnhteifricoastciolenrotifclelessioionnssowf bitohthsptheeciaplroexmimphaal saiosrtoahamndarbkerarschoiof -lecespiohnaplicroagrtesrsyiouns.ing Itcahrneodscsfeib-lslrueolcuatsriocnoampl apfonorasmlityaiostiniso,noBfa)lesqswuioaenllsti,afisDca)intqitoruna-pnoltfaiflqiecusaeitoionmnsaoutrfsiximndgaerekpneorsfsaitcoioefnlae, osEiro)tinsctapirnoeigpnrgaerfsaostriiomnsa,inrkCcel)ursdeiontfegramnpeoincpartotoitosicnisc,oFfr)e IdmeicteroctdioisnseocftiEoRn.sVtriessusalaiznadtioUnPaRnadcqtiuvantiotifnicantidonGo)f qleusaionntifcichatiroanctoefrigseticnseweixllpbrescsaiorrneiudsionugt lbaysemr-ocraphtoumreetric analysis of stained or immunostained sections by video microscopy. In addition, the Core will provide IaBnioaslytastiistoicfalthsuepropsocrltereolsaitsedantod tghendeesxigpnreosfsmioonuasrerasytuddaiteas. (i.e. power calculations) and the quantitative IcInodmivpidaureadlstowithedgiaebnetreasl/pinospulliantiroensiasltahnocuegharteheatmsiegcnhifaicnaisnmtlyisgruenaktneorwrisnk. TfohredLeevseilonpiAngnahlyesairst/dBisioesatsaetistics Core will facilitate the direct assessment of the role of insulin resistance in atherosclerosis, the primary cause Iomfohdeasrtodf iisnetearsvenintioWne. stern societies and elsewhere.These studies """"""""will likely shed light on new therapeutic I I

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL087123-04
Application #
8105446
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
Budget Start
2010-07-01
Budget End
2011-06-30
Support Year
4
Fiscal Year
2010
Total Cost
$320,758
Indirect Cost
Name
Columbia University (N.Y.)
Department
Type
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
Molusky, Matthew M; Hsieh, Joanne; Lee, Samuel X et al. (2018) Metformin and AMP Kinase Activation Increase Expression of the Sterol Transporters ABCG5/8 (ATP-Binding Cassette Transporter G5/G8) With Potential Antiatherogenic Consequences. Arterioscler Thromb Vasc Biol 38:1493-1503
Cai, Bishuang; Kasikara, Canan; Doran, Amanda C et al. (2018) MerTK signaling in macrophages promotes the synthesis of inflammation resolution mediators by suppressing CaMKII activity. Sci Signal 11:
Accili, Domenico (2018) Insulin Action Research and the Future of Diabetes Treatment: The 2017 Banting Medal for Scientific Achievement Lecture. Diabetes 67:1701-1709
Haeusler, Rebecca A; McGraw, Timothy E; Accili, Domenico (2018) Biochemical and cellular properties of insulin receptor signalling. Nat Rev Mol Cell Biol 19:31-44
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Ghorpade, Devram S; Ozcan, Lale; Zheng, Ze et al. (2018) Hepatocyte-secreted DPP4 in obesity promotes adipose inflammation and insulin resistance. Nature 555:673-677
Fredman, Gabrielle; Tabas, Ira (2017) Boosting Inflammation Resolution in Atherosclerosis: The Next Frontier for Therapy. Am J Pathol 187:1211-1221
Doran, Amanda C; Ozcan, Lale; Cai, Bishuang et al. (2017) CAMKII? suppresses an efferocytosis pathway in macrophages and promotes atherosclerotic plaque necrosis. J Clin Invest 127:4075-4089
Tabas, Ira; Lichtman, Andrew H (2017) Monocyte-Macrophages and T Cells in Atherosclerosis. Immunity 47:621-634
Cai, Bishuang; Thorp, Edward B; Doran, Amanda C et al. (2017) MerTK receptor cleavage promotes plaque necrosis and defective resolution in atherosclerosis. J Clin Invest 127:564-568

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