This Program Project consists of four individual related research projects and three cores. This core oversees the administrative needs of the program. The Program Project director (Dr. Nelson) will maintain a staff who are responsible for financial records, progress reports, internal documents necessary for the functioning of the program project, and basic computer hardware and software support. Given that two subcontracts (Project 2 Subcontract with the University of Washington and Core B Subcontract with Cornell University) are off-site, it will be crucial that communication between the projects and Core members and these external individuals be at its maximum level. Therefore, the Administrative Core will be responsible for fostering electronic means of inter-Project/Core communication and scheduling semi-annual retreats that will assemble all the Pis to discuss the progress of the Program Project. At the University of Vermont, the Administrative Core will schedule the monthly Program Project meeting as well as arrange for the scheduled Internal and External Advisory Committee meetings. The Core will also schedule at least 6 research seminars from internationally recognized scientists outside of the University, whose expertise complements the research interests of the Program Project. The Core will provide secretarial and administrative assistance to the Internal and External Advisory Committee. Manuscripts, progress reports, budgets, personnel recruitment, and assistance with other matters and documents intrinsic to the program will be handled by personnel within the Core. Individual principal investigators are responsible for the scientific progress of the functional units they direct and for utilizing the budgets involved. The Program Project Director will critically review, for approval or disapproval, all significant personnel changes (changes in rank, percent effort, persons involved, etc.), all major shifts of money from one listed in the budget of this proposal.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL095488-02
Application #
8311001
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
Budget Start
2011-08-01
Budget End
2012-07-31
Support Year
2
Fiscal Year
2011
Total Cost
$182,040
Indirect Cost
Name
University of Vermont & St Agric College
Department
Type
DUNS #
066811191
City
Burlington
State
VT
Country
United States
Zip Code
05405
Harraz, Osama F; Longden, Thomas A; Hill-Eubanks, David et al. (2018) PIP2 depletion promotes TRPV4 channel activity in mouse brain capillary endothelial cells. Elife 7:
Gomes, Carolina Cavalieri; Gayden, Tenzin; Bajic, Andrea et al. (2018) TRPV4 and KRAS and FGFR1 gain-of-function mutations drive giant cell lesions of the jaw. Nat Commun 9:4572
Harraz, Osama F; Longden, Thomas A; Dabertrand, Fabrice et al. (2018) Endothelial GqPCR activity controls capillary electrical signaling and brain blood flow through PIP2 depletion. Proc Natl Acad Sci U S A 115:E3569-E3577
Koide, Masayo; Moshkforoush, Arash; Tsoukias, Nikolaos M et al. (2018) The yin and yang of KV channels in cerebral small vessel pathologies. Microcirculation 25:
Balbi, Matilde; Koide, Masayo; Schwarzmaier, Susanne M et al. (2017) Acute changes in neurovascular reactivity after subarachnoid hemorrhage in vivo. J Cereb Blood Flow Metab 37:178-187
Li, Yao; Brayden, Joseph E (2017) Rho kinase activity governs arteriolar myogenic depolarization. J Cereb Blood Flow Metab 37:140-152
Syed, Arsalan U; Koide, Masayo; Brayden, Joseph E et al. (2017) Tonic regulation of middle meningeal artery diameter by ATP-sensitive potassium channels. J Cereb Blood Flow Metab :271678X17749392
Balbi, Matilde; Koide, Masayo; Wellman, George C et al. (2017) Inversion of neurovascular coupling after subarachnoid hemorrhage in vivo. J Cereb Blood Flow Metab 37:3625-3634
Hawkins, Virginia E; Takakura, Ana C; Trinh, Ashley et al. (2017) Purinergic regulation of vascular tone in the retrotrapezoid nucleus is specialized to support the drive to breathe. Elife 6:
Baylie, Rachael; Ahmed, Majid; Bonev, Adrian D et al. (2017) Lack of direct effect of adiponectin on vascular smooth muscle cell BKCa channels or Ca2+ signaling in the regulation of small artery pressure-induced constriction. Physiol Rep 5:

Showing the most recent 10 out of 103 publications