Abstract

The overall goal of the Program Project is to understand mechanisms regulating the cerebral vasculature in normal and disease states. All four projects that constitute this PPG are focused on this goal, and each recognizes that experimental success depends on the proper isolation of tissue from euthanized animals, careful implementation of surgical procedures and appropriate post-op care. The top priority of the Animal &Instrumentation Core is. to enhance the success of research projects for each investigator. This includes providing a central means for handling animal populations, ensuring proper conditions for surgical use, and maintaining excellent post-op care of animals. By centralizing these tasks, which are common to all projects, the Animal &Instrumentation Core allows investigators to focus on experimental issues and management unique to each project to enhance experimental success.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL095488-04
Application #
8514694
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
4
Fiscal Year
2013
Total Cost
$368,200
Indirect Cost
$111,125

  Institution

Name
University of Vermont & St Agric College
Department
Type
DUNS #
066811191
City
Burlington
State
VT
Country
United States
Zip Code
05405

  Publications

Harraz, Osama F; Longden, Thomas A; Hill-Eubanks, David et al. (2018) PIP2 depletion promotes TRPV4 channel activity in mouse brain capillary endothelial cells. Elife 7:
Gomes, Carolina Cavalieri; Gayden, Tenzin; Bajic, Andrea et al. (2018) TRPV4 and KRAS and FGFR1 gain-of-function mutations drive giant cell lesions of the jaw. Nat Commun 9:4572
Harraz, Osama F; Longden, Thomas A; Dabertrand, Fabrice et al. (2018) Endothelial GqPCR activity controls capillary electrical signaling and brain blood flow through PIP2 depletion. Proc Natl Acad Sci U S A 115:E3569-E3577
Koide, Masayo; Moshkforoush, Arash; Tsoukias, Nikolaos M et al. (2018) The yin and yang of KV channels in cerebral small vessel pathologies. Microcirculation 25:
Balbi, Matilde; Koide, Masayo; Schwarzmaier, Susanne M et al. (2017) Acute changes in neurovascular reactivity after subarachnoid hemorrhage in vivo. J Cereb Blood Flow Metab 37:178-187
Li, Yao; Brayden, Joseph E (2017) Rho kinase activity governs arteriolar myogenic depolarization. J Cereb Blood Flow Metab 37:140-152
Syed, Arsalan U; Koide, Masayo; Brayden, Joseph E et al. (2017) Tonic regulation of middle meningeal artery diameter by ATP-sensitive potassium channels. J Cereb Blood Flow Metab :271678X17749392
Balbi, Matilde; Koide, Masayo; Wellman, George C et al. (2017) Inversion of neurovascular coupling after subarachnoid hemorrhage in vivo. J Cereb Blood Flow Metab 37:3625-3634
Hawkins, Virginia E; Takakura, Ana C; Trinh, Ashley et al. (2017) Purinergic regulation of vascular tone in the retrotrapezoid nucleus is specialized to support the drive to breathe. Elife 6:
Baylie, Rachael; Ahmed, Majid; Bonev, Adrian D et al. (2017) Lack of direct effect of adiponectin on vascular smooth muscle cell BKCa channels or Ca2+ signaling in the regulation of small artery pressure-induced constriction. Physiol Rep 5:

Showing the most recent 10 out of 103 publications